Physical activity and the risk of colorectal cancer in Lynch syndrome

S. Ghazaleh Dashti, Aung Ko Win, Sheetal S. Hardikar, Stephen E. Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K. Peterson, Y. Nancy You, Daniel D. Buchanan, Jane C. Figueiredo, Peter T. Campbell, Steven Gallinger, Polly A. Newcomb, John D. Potter, Noralane Morey Lindor, Loic Le Marchand, Robert W. Haile, John L. Hopper, Mark A. Jenkins, Karen M. Basen-EngquistPatrick M. Lynch, Mala Pande

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little is known about its relationship with colorectal cancer risk in people with Lynch syndrome, carriers of inherited pathogenic mutations in genes affecting DNA mismatch repair (MMR). We studied a cohort of 2,042 MMR gene mutations carriers (n = 807, diagnosed with colorectal cancer), from the Colon Cancer Family Registry. Self-reported physical activity in three age-periods (20–29, 30–49 and ≥50 years) was summarized as average metabolic equivalent of task hours per week (MET-hr/week) during the age-period of cancer diagnosis or censoring (near-term exposure) and across all age-periods preceding cancer diagnosis or censoring (long-term exposure). Weighted Cox regression was used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for the association between physical activity and colorectal cancer risk. Near-term physical activity was associated with a small reduction in the risk of colorectal cancer (HR ≥35 vs. <3.5 MET-hr/week, 0.71; 95% CI, 0.53–0.96). The strength and direction of associations were similar for long-term physical activity, although the associations were not nominally significant. Our results suggest that physical activity is inversely associated with the risk of colorectal cancer for people with Lynch syndrome; however, further confirmation is warranted. The potential modifying effect of physical activity on colorectal cancer risk in people with Lynch syndrome could be useful for risk prediction and support counseling advice for lifestyle modification to reduce cancer risk.

Original languageEnglish (US)
JournalInternational Journal of Cancer
DOIs
StateAccepted/In press - Jan 1 2018

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Hereditary Nonpolyposis Colorectal Neoplasms
Colorectal Neoplasms
Metabolic Equivalent
DNA Mismatch Repair
Colonic Neoplasms
Confidence Intervals
Neoplasms
Mutation
Risk Reduction Behavior
Genes
Registries
Life Style
Counseling

Keywords

  • colorectal cancer
  • Lynch syndrome
  • mismatch repair
  • physical activity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Dashti, S. G., Win, A. K., Hardikar, S. S., Glombicki, S. E., Mallenahalli, S., Thirumurthi, S., ... Pande, M. (Accepted/In press). Physical activity and the risk of colorectal cancer in Lynch syndrome. International Journal of Cancer. https://doi.org/10.1002/ijc.31611

Physical activity and the risk of colorectal cancer in Lynch syndrome. / Dashti, S. Ghazaleh; Win, Aung Ko; Hardikar, Sheetal S.; Glombicki, Stephen E.; Mallenahalli, Sheila; Thirumurthi, Selvi; Peterson, Susan K.; You, Y. Nancy; Buchanan, Daniel D.; Figueiredo, Jane C.; Campbell, Peter T.; Gallinger, Steven; Newcomb, Polly A.; Potter, John D.; Lindor, Noralane Morey; Le Marchand, Loic; Haile, Robert W.; Hopper, John L.; Jenkins, Mark A.; Basen-Engquist, Karen M.; Lynch, Patrick M.; Pande, Mala.

In: International Journal of Cancer, 01.01.2018.

Research output: Contribution to journalArticle

Dashti, SG, Win, AK, Hardikar, SS, Glombicki, SE, Mallenahalli, S, Thirumurthi, S, Peterson, SK, You, YN, Buchanan, DD, Figueiredo, JC, Campbell, PT, Gallinger, S, Newcomb, PA, Potter, JD, Lindor, NM, Le Marchand, L, Haile, RW, Hopper, JL, Jenkins, MA, Basen-Engquist, KM, Lynch, PM & Pande, M 2018, 'Physical activity and the risk of colorectal cancer in Lynch syndrome', International Journal of Cancer. https://doi.org/10.1002/ijc.31611
Dashti SG, Win AK, Hardikar SS, Glombicki SE, Mallenahalli S, Thirumurthi S et al. Physical activity and the risk of colorectal cancer in Lynch syndrome. International Journal of Cancer. 2018 Jan 1. https://doi.org/10.1002/ijc.31611
Dashti, S. Ghazaleh ; Win, Aung Ko ; Hardikar, Sheetal S. ; Glombicki, Stephen E. ; Mallenahalli, Sheila ; Thirumurthi, Selvi ; Peterson, Susan K. ; You, Y. Nancy ; Buchanan, Daniel D. ; Figueiredo, Jane C. ; Campbell, Peter T. ; Gallinger, Steven ; Newcomb, Polly A. ; Potter, John D. ; Lindor, Noralane Morey ; Le Marchand, Loic ; Haile, Robert W. ; Hopper, John L. ; Jenkins, Mark A. ; Basen-Engquist, Karen M. ; Lynch, Patrick M. ; Pande, Mala. / Physical activity and the risk of colorectal cancer in Lynch syndrome. In: International Journal of Cancer. 2018.
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