Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nikos Papadimitriou; Niki Dimou; Konstantinos K. Tsilidis; Barbara Banbury; Richard M. Martin; Sarah J. Lewis; Nabila Kazmi; Timothy M. Robinson; Demetrius Albanes; Krasimira Aleksandrova; Sonja I. Berndt; D. Timothy Bishop; Hermann Brenner; Daniel D. Buchanan; Bas Bueno-de-Mesquita; Peter T. Campbell; Sergi Castellví-Bel; Andrew T. Chan; Jenny Chang-Claude; Merete Ellingjord-Dale; Jane C. Figueiredo; Steven J. Gallinger; Graham G. Giles; Edward Giovannucci; Stephen B. Gruber; Andrea Gsur; Jochen Hampe; Heather Hampel; Sophia Harlid; Tabitha A. Harrison; Michael Hoffmeister; John L. Hopper; Li Hsu; José María Huerta; Jeroen R. Huyghe; Mark A. Jenkins; Temitope O. Keku; Tilman Kühn; Carlo La Vecchia; Loic Le Marchand; Christopher I. Li; Li Li; Annika Lindblom; Noralane M. Lindor; Brigid Lynch; Sanford D. Markowitz; Giovanna Masala; Anne M. May; Roger Milne; Evelyn Monninkhof; Lorena Moreno; Victor Moreno; Polly A. Newcomb; Kenneth Offit; Vittorio Perduca; Paul D.P. Pharoah; Elizabeth A. Platz; John D. Potter; Gad Rennert; Elio Riboli; Maria Jose Sánchez; Stephanie L. Schmit; Robert E. Schoen; Gianluca Severi; Sabina Sieri; Martha L. Slattery; Mingyang Song; Catherine M. Tangen; Stephen N. Thibodeau; Ruth C. Travis; Antonia Trichopoulou; Cornelia M. Ulrich; Franzel J.B. van Duijnhoven; Bethany Van Guelpen; Pavel Vodicka; Emily White; Alicja Wolk; Michael O. Woods; Anna H. Wu; Ulrike Peters; Marc J. Gunter; Neil Murphy

doi:10.1038/s41467-020-14389-8

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Nikos Papadimitriou, Niki Dimou, Konstantinos K. Tsilidis, Barbara Banbury, Richard M. Martin, Sarah J. Lewis, Nabila Kazmi, Timothy M. Robinson, Demetrius Albanes, Krasimira Aleksandrova, Sonja I. Berndt, D. Timothy Bishop, Hermann Brenner, Daniel D. Buchanan, Bas Bueno-de-Mesquita, Peter T. Campbell, Sergi Castellví-Bel, Andrew T. Chan, Jenny Chang-Claude, Merete Ellingjord-DaleJane C. Figueiredo, Steven J. Gallinger, Graham G. Giles, Edward Giovannucci, Stephen B. Gruber, Andrea Gsur, Jochen Hampe, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Michael Hoffmeister, John L. Hopper, Li Hsu, José María Huerta, Jeroen R. Huyghe, Mark A. Jenkins, Temitope O. Keku, Tilman Kühn, Carlo La Vecchia, Loic Le Marchand, Christopher I. Li, Li Li, Annika Lindblom, Noralane M. Lindor, Brigid Lynch, Sanford D. Markowitz, Giovanna Masala, Anne M. May, Roger Milne, Evelyn Monninkhof, Lorena Moreno, Victor Moreno, Polly A. Newcomb, Kenneth Offit, Vittorio Perduca, Paul D.P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Elio Riboli, Maria Jose Sánchez, Stephanie L. Schmit, Robert E. Schoen, Gianluca Severi, Sabina Sieri, Martha L. Slattery, Mingyang Song, Catherine M. Tangen, Stephen N. Thibodeau, Ruth C. Travis, Antonia Trichopoulou, Cornelia M. Ulrich, Franzel J.B. van Duijnhoven, Bethany Van Guelpen, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Marc J. Gunter, Neil Murphy

Research output: Contribution to journal › Article › peer-review

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Abstract

Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER^+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

Original language	English (US)
Article number	597
Journal	Nature communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-14389-8
State	Published - Dec 1 2020

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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Papadimitriou, N., Dimou, N., Tsilidis, K. K., Banbury, B., Martin, R. M., Lewis, S. J., Kazmi, N., Robinson, T. M., Albanes, D., Aleksandrova, K., Berndt, S. I., Timothy Bishop, D., Brenner, H., Buchanan, D. D., Bueno-de-Mesquita, B., Campbell, P. T., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., ... Murphy, N. (2020). Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nature communications, 11(1), Article 597. https://doi.org/10.1038/s41467-020-14389-8

Papadimitriou, N, Dimou, N, Tsilidis, KK, Banbury, B, Martin, RM, Lewis, SJ, Kazmi, N, Robinson, TM, Albanes, D, Aleksandrova, K, Berndt, SI, Timothy Bishop, D, Brenner, H, Buchanan, DD, Bueno-de-Mesquita, B, Campbell, PT, Castellví-Bel, S, Chan, AT, Chang-Claude, J, Ellingjord-Dale, M, Figueiredo, JC, Gallinger, SJ, Giles, GG, Giovannucci, E, Gruber, SB, Gsur, A, Hampe, J, Hampel, H, Harlid, S, Harrison, TA, Hoffmeister, M, Hopper, JL, Hsu, L, María Huerta, J, Huyghe, JR, Jenkins, MA, Keku, TO, Kühn, T, La Vecchia, C, Le Marchand, L, Li, CI, Li, L, Lindblom, A, Lindor, NM, Lynch, B, Markowitz, SD, Masala, G, May, AM, Milne, R, Monninkhof, E, Moreno, L, Moreno, V, Newcomb, PA, Offit, K, Perduca, V, Pharoah, PDP, Platz, EA, Potter, JD, Rennert, G, Riboli, E, Sánchez, MJ, Schmit, SL, Schoen, RE, Severi, G, Sieri, S, Slattery, ML, Song, M, Tangen, CM, Thibodeau, SN, Travis, RC, Trichopoulou, A, Ulrich, CM, van Duijnhoven, FJB, Van Guelpen, B, Vodicka, P, White, E, Wolk, A, Woods, MO, Wu, AH, Peters, U, Gunter, MJ & Murphy, N 2020, 'Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis', Nature communications, vol. 11, no. 1, 597. https://doi.org/10.1038/s41467-020-14389-8

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abstract = "Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.",

author = "Nikos Papadimitriou and Niki Dimou and Tsilidis, {Konstantinos K.} and Barbara Banbury and Martin, {Richard M.} and Lewis, {Sarah J.} and Nabila Kazmi and Robinson, {Timothy M.} and Demetrius Albanes and Krasimira Aleksandrova and Berndt, {Sonja I.} and {Timothy Bishop}, D. and Hermann Brenner and Buchanan, {Daniel D.} and Bas Bueno-de-Mesquita and Campbell, {Peter T.} and Sergi Castellv{\'i}-Bel and Chan, {Andrew T.} and Jenny Chang-Claude and Merete Ellingjord-Dale and Figueiredo, {Jane C.} and Gallinger, {Steven J.} and Giles, {Graham G.} and Edward Giovannucci and Gruber, {Stephen B.} and Andrea Gsur and Jochen Hampe and Heather Hampel and Sophia Harlid and Harrison, {Tabitha A.} and Michael Hoffmeister and Hopper, {John L.} and Li Hsu and {Mar{\'i}a Huerta}, Jos{\'e} and Huyghe, {Jeroen R.} and Jenkins, {Mark A.} and Keku, {Temitope O.} and Tilman K{\"u}hn and {La Vecchia}, Carlo and {Le Marchand}, Loic and Li, {Christopher I.} and Li Li and Annika Lindblom and Lindor, {Noralane M.} and Brigid Lynch and Markowitz, {Sanford D.} and Giovanna Masala and May, {Anne M.} and Roger Milne and Evelyn Monninkhof and Lorena Moreno and Victor Moreno and Newcomb, {Polly A.} and Kenneth Offit and Vittorio Perduca and Pharoah, {Paul D.P.} and Platz, {Elizabeth A.} and Potter, {John D.} and Gad Rennert and Elio Riboli and S{\'a}nchez, {Maria Jose} and Schmit, {Stephanie L.} and Schoen, {Robert E.} and Gianluca Severi and Sabina Sieri and Slattery, {Martha L.} and Mingyang Song and Tangen, {Catherine M.} and Thibodeau, {Stephen N.} and Travis, {Ruth C.} and Antonia Trichopoulou and Ulrich, {Cornelia M.} and {van Duijnhoven}, {Franzel J.B.} and {Van Guelpen}, Bethany and Pavel Vodicka and Emily White and Alicja Wolk and Woods, {Michael O.} and Wu, {Anna H.} and Ulrike Peters and Gunter, {Marc J.} and Neil Murphy",

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doi = "10.1038/s41467-020-14389-8",

language = "English (US)",

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T2 - a Mendelian randomisation analysis

AU - Papadimitriou, Nikos

AU - Dimou, Niki

AU - Tsilidis, Konstantinos K.

AU - Banbury, Barbara

AU - Martin, Richard M.

AU - Lewis, Sarah J.

AU - Kazmi, Nabila

AU - Robinson, Timothy M.

AU - Albanes, Demetrius

AU - Aleksandrova, Krasimira

AU - Berndt, Sonja I.

AU - Timothy Bishop, D.

AU - Brenner, Hermann

AU - Buchanan, Daniel D.

AU - Bueno-de-Mesquita, Bas

AU - Campbell, Peter T.

AU - Castellví-Bel, Sergi

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Ellingjord-Dale, Merete

AU - Figueiredo, Jane C.

AU - Gallinger, Steven J.

AU - Giles, Graham G.

AU - Giovannucci, Edward

AU - Gruber, Stephen B.

AU - Gsur, Andrea

AU - Hampe, Jochen

AU - Hampel, Heather

AU - Harlid, Sophia

AU - Harrison, Tabitha A.

AU - Hoffmeister, Michael

AU - Hopper, John L.

AU - Hsu, Li

AU - María Huerta, José

AU - Huyghe, Jeroen R.

AU - Jenkins, Mark A.

AU - Keku, Temitope O.

AU - Kühn, Tilman

AU - La Vecchia, Carlo

AU - Le Marchand, Loic

AU - Li, Christopher I.

AU - Li, Li

AU - Lindblom, Annika

AU - Lindor, Noralane M.

AU - Lynch, Brigid

AU - Markowitz, Sanford D.

AU - Masala, Giovanna

AU - May, Anne M.

AU - Milne, Roger

AU - Monninkhof, Evelyn

AU - Moreno, Lorena

AU - Moreno, Victor

AU - Newcomb, Polly A.

AU - Offit, Kenneth

AU - Perduca, Vittorio

AU - Pharoah, Paul D.P.

AU - Platz, Elizabeth A.

AU - Potter, John D.

AU - Rennert, Gad

AU - Riboli, Elio

AU - Sánchez, Maria Jose

AU - Schmit, Stephanie L.

AU - Schoen, Robert E.

AU - Severi, Gianluca

AU - Sieri, Sabina

AU - Slattery, Martha L.

AU - Song, Mingyang

AU - Tangen, Catherine M.

AU - Thibodeau, Stephen N.

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Ulrich, Cornelia M.

AU - van Duijnhoven, Franzel J.B.

AU - Van Guelpen, Bethany

AU - Vodicka, Pavel

AU - White, Emily

AU - Wolk, Alicja

AU - Woods, Michael O.

AU - Wu, Anna H.

AU - Peters, Ulrike

AU - Gunter, Marc J.

AU - Murphy, Neil

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

AB - Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

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