TY - JOUR
T1 - Physical Activity and Angiotensin-Converting Enzyme Gene Polymorphism in Mild Hypertensives
AU - Winnicki, Mikolaj
AU - Accurso, Valentina
AU - Hoffmann, Michal
AU - Pawlowski, Ryszard
AU - Dorigatti, Francesca
AU - Santonastaso, Massimo
AU - Longo, Daniele
AU - Krupa-Wojciechowska, Barbara
AU - Jeunemaitre, Xavier
AU - Pessina, Achille C.
AU - Somers, Virend K.
AU - Palatini, Paolo
PY - 2004/2/15
Y1 - 2004/2/15
N2 - It has been suggested that the insertion(I) allele of the I/deletion(D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with endurance exercise and increased physical conditioning in response to this type of exercise. To investigate the association between the ACE I/D polymorphism and physical activity status in 355 never treated, stage I hypertensives (265 men, 90 women, mean age: 33 ± 9 years), in whom power exercise is contraindicated, participants of the HARVEST study. Physical activity was assessed using a standardized questionnaire. BMI and age did not vary among genotypes. None of active subjects performed power oriented exercises. ACE I/D frequencies (II-18%,ID-55%,DD-27%) were in Hardy-Weinberg equilibrium. Sedentary lifestyle was more common among DD than II hypertensives (76% in DD, and 48% in II, χ2 = 13.9, P=0.001). In stepwise MANOVA using age, marital status, profession, sex, and ACE genotype as predictors of physical activity, marital status (F = 24.4, P < 0.0001) and ACE genotype (F = 16.03, P < 0.0001) contributed to more than 50% of the variance in physical activity status of the population. Our results suggest that the ACE I/D polymorphism may be a specific genetic factor associated with physical activity levels in free-living borderline and mild hypertensive subjects.
AB - It has been suggested that the insertion(I) allele of the I/deletion(D) polymorphism of the angiotensin converting enzyme (ACE) gene is associated with endurance exercise and increased physical conditioning in response to this type of exercise. To investigate the association between the ACE I/D polymorphism and physical activity status in 355 never treated, stage I hypertensives (265 men, 90 women, mean age: 33 ± 9 years), in whom power exercise is contraindicated, participants of the HARVEST study. Physical activity was assessed using a standardized questionnaire. BMI and age did not vary among genotypes. None of active subjects performed power oriented exercises. ACE I/D frequencies (II-18%,ID-55%,DD-27%) were in Hardy-Weinberg equilibrium. Sedentary lifestyle was more common among DD than II hypertensives (76% in DD, and 48% in II, χ2 = 13.9, P=0.001). In stepwise MANOVA using age, marital status, profession, sex, and ACE genotype as predictors of physical activity, marital status (F = 24.4, P < 0.0001) and ACE genotype (F = 16.03, P < 0.0001) contributed to more than 50% of the variance in physical activity status of the population. Our results suggest that the ACE I/D polymorphism may be a specific genetic factor associated with physical activity levels in free-living borderline and mild hypertensive subjects.
KW - Angiotensin converting enzyme gene polymorphism
KW - Endurance
KW - Mild hypertensives
KW - Physical activity
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U2 - 10.1002/ajmg.a.20434
DO - 10.1002/ajmg.a.20434
M3 - Article
C2 - 14755464
AN - SCOPUS:10744228245
SN - 1552-4825
VL - 125 A
SP - 38
EP - 44
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 1
ER -