Phototherapy of Barrett's esophagus

Kenneth K. Wang, Kumar Gutta, Mark A. Laukka

Research output: Contribution to journalConference article

Abstract

Barrett's esophagus is a common pre-malignant disease. The aim of this study is to determine if low dose photodynamic therapy is capable of ablating Barrett's epithelium allowing regrowth of normal squamous mucosa. Methods: Patients with specialized Barrett's esophagus of at least 3 cm length were given 1 .5-1.75 mg/kg of hematoporphyrin derivative intravenously. After 48 hours, esophagoscopy and videotaping of the Barrett's was performed. A 1.0-1.5 cm cylindrical diffusing fiber delivered light of 630 nm in a dose of 150-200 J/cm using a tunable dye laser at a power of 400 mW/cm. Following entry, patients were placed on omeprazole 20 mg/day for 6 months. Results: Twelve patients (8 men) mean age of 62±4 have had repeat endoscopy performed at 25±2 weeks following entry. The Barrett's segment length decreased from 8±1 to 5±1 cm after PDT (p < 0.01 ) with a corresponding change in the appearance and location of the squamocolumnar junction. Six (50%) of the patients had a 4 cm or more decrease in the length of their Barrett's esophagus with normal squamous mucosa on biopsy. Adverse events included transient odynophagia, minor sunburn, and transient chest pain. Conclusions: Photodynamic therapy of Barrett's esophagus can cause a regression in length of the Barrett's segment with replacement by normal squamous epithelium.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume2133
DOIs
StatePublished - Jul 19 1994
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994 - Los Angeles, United States
Duration: Jan 23 1994Jan 29 1994

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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