Photoproteins as models of drug receptors

John R. Blinks, David G. Allen, Franklyn G. Prendergast, Gary C. Harrer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The calcium-sensitive photoprotein aequorin has properties that make it well suited for studies of protein-ligand interactions. Its behavior resembles that of classical drug receptors in many ways. A two-state model reproduces many of the properties of aequorin, including two that are not consistent with the conventional occupancy model.

Original languageEnglish (US)
Pages (from-to)1237-1244
Number of pages8
JournalLife Sciences
Volume22
Issue number13-15
DOIs
StatePublished - Apr 1978

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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