Photodynamic therapy for early stage squamous cell carcinoma of the lung

Denis A. Cortese, Eric Edell, James H. Kinsey

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Objective: To study the effectiveness of photodynamic therapy (PDT) as a therapeutic strategy in roentgenographically occult squamous cell carcinoma of the lung. Material and Methods: A carefully selected group of 21 patients (with 23 cancers) who had early stage squamous cell carcinoma of the lung and were eligible for surgical treatment were offered PDT as an alternative to resection. Patients underwent close follow-up with bronchoscopic surveillance and were offered resection if cancer persisted after no more than two sessions of PDT. Results: A complete response was identified in 15 patients (16 cancers) after an initial PDT session. A complete response that lasted longer than 12 months was noted in 11 patients (52%). After PDT, the minimal follow-up period was 24 months. A subsequent primary lung cancer developed in 5 of the 21 patients(24%). Ten patients ultimately had surgical treatment, in 3 (30%) of whom N1 disease was identified at the time of resection. Two patients refused a surgical procedure and received alternative therapy. Therefore, nine patients (43%) were spared an operation (95% confidence interval, 21.8 to 66.6%). The mean duration of follow-up for these nine patients was 68 months (range, 24 to 116). Conclusion: On the basis of this investigation, we can conclude with 95% confidence that at least 22% of patients with early stage squamous cell lung cancer who are candidates for PDT can be spared surgical resection.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalMayo Clinic Proceedings
Volume72
Issue number7
StatePublished - Jan 1 1997

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Photochemotherapy
Squamous Cell Carcinoma
Lung
Lung Neoplasms
Squamous Cell Neoplasms
Neoplasms
Complementary Therapies
Therapeutics
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Photodynamic therapy for early stage squamous cell carcinoma of the lung. / Cortese, Denis A.; Edell, Eric; Kinsey, James H.

In: Mayo Clinic Proceedings, Vol. 72, No. 7, 01.01.1997, p. 595-602.

Research output: Contribution to journalArticle

Cortese, Denis A. ; Edell, Eric ; Kinsey, James H. / Photodynamic therapy for early stage squamous cell carcinoma of the lung. In: Mayo Clinic Proceedings. 1997 ; Vol. 72, No. 7. pp. 595-602.
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