TY - JOUR
T1 - Photodynamic therapy for Barrett's esophagus
T2 - Does light still have a role?
AU - Wang, Kenneth K.
AU - Lutzke, L.
AU - Borkenhagen, L.
AU - Westra, W.
AU - Song, M. W.K.
AU - Prasad, G.
AU - Buttar, N. S.
PY - 2008/12
Y1 - 2008/12
N2 - Photodynamic therapy was the first treatment to have been shown to significantly decrease high-grade dysplasia and cancer in patients with Barrett's esophagus. However, its use has been limited, primarily because of the side effects, which include esophageal strictures, cutaneous photosensitivity, chest pain, and nausea and vomiting [1]. The tolerability aspects of photodynamic therapy, as well as the dosimetry, though, can be improved with existing technologies to further develop this therapy into truly a widely applicable therapy. Studies have recently been done to help identify patients more likely to suffer stricture after photodynamic therapy. In addition, there has been evidence to suggest that the efficacy of photodynamic therapy also can be limited by genetic abnormalities in the mucosa. By combining knowledge of tissue biology, optical properties of the tissue, and dosimetry issues with ablation, photodynamic therapy can still have a potentially bright future.
AB - Photodynamic therapy was the first treatment to have been shown to significantly decrease high-grade dysplasia and cancer in patients with Barrett's esophagus. However, its use has been limited, primarily because of the side effects, which include esophageal strictures, cutaneous photosensitivity, chest pain, and nausea and vomiting [1]. The tolerability aspects of photodynamic therapy, as well as the dosimetry, though, can be improved with existing technologies to further develop this therapy into truly a widely applicable therapy. Studies have recently been done to help identify patients more likely to suffer stricture after photodynamic therapy. In addition, there has been evidence to suggest that the efficacy of photodynamic therapy also can be limited by genetic abnormalities in the mucosa. By combining knowledge of tissue biology, optical properties of the tissue, and dosimetry issues with ablation, photodynamic therapy can still have a potentially bright future.
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U2 - 10.1055/s-0028-1103405
DO - 10.1055/s-0028-1103405
M3 - Review article
C2 - 19065486
AN - SCOPUS:58149096840
SN - 0013-726X
VL - 40
SP - 1021
EP - 1025
JO - Endoscopy
JF - Endoscopy
IS - 12
ER -