Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia

Paolo Ortu; Glenn M. LaMuraglia; W. Gregory Roberts; Kevin T. Schomacker; Thomas F. Deutsch; Thomas J Flotte; Tayyaba Hasan

doi:10.1117/12.137458

Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia

Paolo Ortu, Glenn M. LaMuraglia, W. Gregory Roberts, Kevin T. Schomacker, Thomas F. Deutsch, Thomas J Flotte, Tayyaba Hasan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.

Original language	English (US)
Title of host publication	Laser-Tissue Interaction III
Publisher	SPIE
Pages	188-194
Number of pages	7
Volume	1646
ISBN (Electronic)	9780819407924
DOIs	https://doi.org/10.1117/12.137458
State	Published - Aug 7 1992
Externally published	Yes
Event	Laser-Tissue Interaction III 1992 - Los Angeles, United States Duration: Jan 19 1992 → Jan 24 1992

Other

Other	Laser-Tissue Interaction III 1992
Country/Territory	United States
City	Los Angeles
Period	1/19/92 → 1/24/92

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.137458

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title = "Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia",

abstract = "The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.",

author = "Paolo Ortu and LaMuraglia, {Glenn M.} and Roberts, {W. Gregory} and Schomacker, {Kevin T.} and Deutsch, {Thomas F.} and Flotte, {Thomas J} and Tayyaba Hasan",

year = "1992",

month = aug,

day = "7",

doi = "10.1117/12.137458",

language = "English (US)",

volume = "1646",

pages = "188--194",

booktitle = "Laser-Tissue Interaction III",

publisher = "SPIE",

note = "Laser-Tissue Interaction III 1992 ; Conference date: 19-01-1992 Through 24-01-1992",

}

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T1 - Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia

AU - Ortu, Paolo

AU - LaMuraglia, Glenn M.

AU - Roberts, W. Gregory

AU - Schomacker, Kevin T.

AU - Deutsch, Thomas F.

AU - Flotte, Thomas J

AU - Hasan, Tayyaba

PY - 1992/8/7

Y1 - 1992/8/7

N2 - The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.

AB - The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.

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DO - 10.1117/12.137458

M3 - Conference contribution

AN - SCOPUS:85037541285

VL - 1646

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EP - 194

BT - Laser-Tissue Interaction III

PB - SPIE

T2 - Laser-Tissue Interaction III 1992

Y2 - 19 January 1992 through 24 January 1992

ER -

Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia

Abstract

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