Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia

Paolo Ortu, Glenn M. LaMuraglia, W. Gregory Roberts, Kevin T. Schomacker, Thomas F. Deutsch, Thomas J Flotte, Tayyaba Hasan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The present study uses photodynamic therapy (PDT) for the treatment of IH in the rat carotid artery model. PDT is a relatively new cancer treatment technique which utilizes light-activated photosensitizers (PS) to produce injury to targeted cells. PS have no cytotoxic effects unless they are activated by the appropriate wavelength of light. Upon absorption of a photon, the activated PS can either by directly cytotoxic or give rise to cytotoxic oxygen species, commonly singlet oxygen, via energy transfer to the ground state molecular oxygen. Singlet oxygen then becomes the mediator of cellular injury by affecting cellular membranes and subcellular organelles.

Original languageEnglish (US)
Title of host publicationLaser-Tissue Interaction III
PublisherSPIE
Pages188-194
Number of pages7
Volume1646
ISBN (Electronic)9780819407924
DOIs
StatePublished - Aug 7 1992
Externally publishedYes
EventLaser-Tissue Interaction III 1992 - Los Angeles, United States
Duration: Jan 19 1992Jan 24 1992

Other

OtherLaser-Tissue Interaction III 1992
CountryUnited States
CityLos Angeles
Period1/19/921/24/92

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Ortu, P., LaMuraglia, G. M., Roberts, W. G., Schomacker, K. T., Deutsch, T. F., Flotte, T. J., & Hasan, T. (1992). Photochemical effects of chloroaluminum-sulfonated phthalocyanine in arteries with intimai hyperplasia. In Laser-Tissue Interaction III (Vol. 1646, pp. 188-194). SPIE. https://doi.org/10.1117/12.137458