@article{b897325137384af284e1c07dd5df194d,
title = "Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression",
abstract = "RB is known to act as a tumor suppressor by inhibiting E2F transcription factors, and this function is abolished due to its phosphorylation by CDKs. Jin et al. identify a previously uncharacterized tumor suppressor role of CDK4/6-phosphorylated RB in promoting cancer immunity via inhibition of NF-κB transcriptional activity and PD-L1 expression.",
keywords = "CDK4/6 inhibitor, CHD1, MAP3K7, NF-κB, PD-L1, RB, immunotherapy, phosphorylation, prostate cancer, radiotherapy",
author = "Xin Jin and Donglin Ding and Yuqian Yan and Hui Li and Bo Wang and Linlin Ma and Zhenqing Ye and Tao Ma and Qiang Wu and Rodrigues, {Daniel N.} and Manish Kohli and Rafael Jimenez and Liguo Wang and Goodrich, {David W.} and {de Bono}, Johann and Haidong Dong and Heshui Wu and Runzhi Zhu and Haojie Huang",
note = "Funding Information: We thank the patients and their families for their altruism in participating in research studies. This work was supported in part by the Mayo Clinic Foundation (to H.H.) and the National Natural Science Foundation of China ( 81702374 to X.J.). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "3",
doi = "10.1016/j.molcel.2018.10.034",
language = "English (US)",
volume = "73",
pages = "22--35.e6",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "1",
}