Abstract
RB is known to act as a tumor suppressor by inhibiting E2F transcription factors, and this function is abolished due to its phosphorylation by CDKs. Jin et al. identify a previously uncharacterized tumor suppressor role of CDK4/6-phosphorylated RB in promoting cancer immunity via inhibition of NF-κB transcriptional activity and PD-L1 expression.
Original language | English (US) |
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Pages (from-to) | 22-35.e6 |
Journal | Molecular Cell |
Volume | 73 |
Issue number | 1 |
DOIs | |
State | Published - Jan 3 2019 |
Keywords
- CDK4/6 inhibitor
- CHD1
- MAP3K7
- NF-κB
- PD-L1
- RB
- immunotherapy
- phosphorylation
- prostate cancer
- radiotherapy
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology