Phosphatidylcholine and choline homeostasis

Zhaoyu Li, Dennis E. Vance

Research output: Contribution to journalArticle

283 Citations (Scopus)

Abstract

Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to PC followed by catabolism to choline. The main fate of choline is the synthesis of PC. In addition, choline is oxidized to betaine in kidney and liver and converted to acetylcholine in the nervous system. Mice that lack choline kinase (CK) α die during embryogenesis, whereas mice that lack CKβ unexpectedly develop muscular dystrophy. Mice that lack CTP:phosphocholine cytidylyltransferase (CT) α also die during early embryogenesis, whereas mice that lack CTβ exhibit gonadal dysfunction. The cytidylyltransferase β isoform also plays a role in the branching of axons of neurons. An alternative PC biosynthetic pathway in the liver uses phosphatidylethanolamine N-methyltransferase to catalyze the formation of PC from PE. Mice that lack the methyltransferase survive but die from steatohepatitis and liver failure when placed on a choline-deficient diet. Hence, choline is an essential nutrient. PC biosynthesis is required for normal very low density lipoprotein secretion from hepatocytes. Recent studies indicate that choline is recycled in the liver and redistributed from kidney, lung, and intestine to liver and brain when choline supply is attenuated.

Original languageEnglish (US)
Pages (from-to)1187-1194
Number of pages8
JournalJournal of Lipid Research
Volume49
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

Choline
Phosphatidylcholines
Homeostasis
Liver
Choline Kinase
Nutrition
Embryonic Development
Phosphatidylethanolamine N-Methyltransferase
Choline-Phosphate Cytidylyltransferase
Cytidine Diphosphate Choline
Diet
Kidney
Betaine
VLDL Lipoproteins
Muscular Dystrophies
Biosynthesis
Biosynthetic Pathways
Liver Failure
Methyltransferases
Neurology

Keywords

  • Choline recycling
  • Choline redistribution
  • Lipoproteins
  • Phosphatidylethanolamine
  • Phosphatidylethanolamine N-methyltransferase

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

Phosphatidylcholine and choline homeostasis. / Li, Zhaoyu; Vance, Dennis E.

In: Journal of Lipid Research, Vol. 49, No. 6, 01.06.2008, p. 1187-1194.

Research output: Contribution to journalArticle

Li, Zhaoyu ; Vance, Dennis E. / Phosphatidylcholine and choline homeostasis. In: Journal of Lipid Research. 2008 ; Vol. 49, No. 6. pp. 1187-1194.
@article{1fe28a47c45947f8bd926152db2b007c,
title = "Phosphatidylcholine and choline homeostasis",
abstract = "Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to PC followed by catabolism to choline. The main fate of choline is the synthesis of PC. In addition, choline is oxidized to betaine in kidney and liver and converted to acetylcholine in the nervous system. Mice that lack choline kinase (CK) α die during embryogenesis, whereas mice that lack CKβ unexpectedly develop muscular dystrophy. Mice that lack CTP:phosphocholine cytidylyltransferase (CT) α also die during early embryogenesis, whereas mice that lack CTβ exhibit gonadal dysfunction. The cytidylyltransferase β isoform also plays a role in the branching of axons of neurons. An alternative PC biosynthetic pathway in the liver uses phosphatidylethanolamine N-methyltransferase to catalyze the formation of PC from PE. Mice that lack the methyltransferase survive but die from steatohepatitis and liver failure when placed on a choline-deficient diet. Hence, choline is an essential nutrient. PC biosynthesis is required for normal very low density lipoprotein secretion from hepatocytes. Recent studies indicate that choline is recycled in the liver and redistributed from kidney, lung, and intestine to liver and brain when choline supply is attenuated.",
keywords = "Choline recycling, Choline redistribution, Lipoproteins, Phosphatidylethanolamine, Phosphatidylethanolamine N-methyltransferase",
author = "Zhaoyu Li and Vance, {Dennis E.}",
year = "2008",
month = "6",
day = "1",
doi = "10.1194/jlr.R700019-JLR200",
language = "English (US)",
volume = "49",
pages = "1187--1194",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "6",

}

TY - JOUR

T1 - Phosphatidylcholine and choline homeostasis

AU - Li, Zhaoyu

AU - Vance, Dennis E.

PY - 2008/6/1

Y1 - 2008/6/1

N2 - Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to PC followed by catabolism to choline. The main fate of choline is the synthesis of PC. In addition, choline is oxidized to betaine in kidney and liver and converted to acetylcholine in the nervous system. Mice that lack choline kinase (CK) α die during embryogenesis, whereas mice that lack CKβ unexpectedly develop muscular dystrophy. Mice that lack CTP:phosphocholine cytidylyltransferase (CT) α also die during early embryogenesis, whereas mice that lack CTβ exhibit gonadal dysfunction. The cytidylyltransferase β isoform also plays a role in the branching of axons of neurons. An alternative PC biosynthetic pathway in the liver uses phosphatidylethanolamine N-methyltransferase to catalyze the formation of PC from PE. Mice that lack the methyltransferase survive but die from steatohepatitis and liver failure when placed on a choline-deficient diet. Hence, choline is an essential nutrient. PC biosynthesis is required for normal very low density lipoprotein secretion from hepatocytes. Recent studies indicate that choline is recycled in the liver and redistributed from kidney, lung, and intestine to liver and brain when choline supply is attenuated.

AB - Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to PC followed by catabolism to choline. The main fate of choline is the synthesis of PC. In addition, choline is oxidized to betaine in kidney and liver and converted to acetylcholine in the nervous system. Mice that lack choline kinase (CK) α die during embryogenesis, whereas mice that lack CKβ unexpectedly develop muscular dystrophy. Mice that lack CTP:phosphocholine cytidylyltransferase (CT) α also die during early embryogenesis, whereas mice that lack CTβ exhibit gonadal dysfunction. The cytidylyltransferase β isoform also plays a role in the branching of axons of neurons. An alternative PC biosynthetic pathway in the liver uses phosphatidylethanolamine N-methyltransferase to catalyze the formation of PC from PE. Mice that lack the methyltransferase survive but die from steatohepatitis and liver failure when placed on a choline-deficient diet. Hence, choline is an essential nutrient. PC biosynthesis is required for normal very low density lipoprotein secretion from hepatocytes. Recent studies indicate that choline is recycled in the liver and redistributed from kidney, lung, and intestine to liver and brain when choline supply is attenuated.

KW - Choline recycling

KW - Choline redistribution

KW - Lipoproteins

KW - Phosphatidylethanolamine

KW - Phosphatidylethanolamine N-methyltransferase

UR - http://www.scopus.com/inward/record.url?scp=43249110882&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43249110882&partnerID=8YFLogxK

U2 - 10.1194/jlr.R700019-JLR200

DO - 10.1194/jlr.R700019-JLR200

M3 - Article

C2 - 18204095

AN - SCOPUS:43249110882

VL - 49

SP - 1187

EP - 1194

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 6

ER -