Phosphate sensing

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

PURPOSE OF REVIEW: To discuss findings suggesting the presence of a phosphate-sensing mechanism in the various organs and the presence of a novel intestinal effector that alters renal phosphate excretion after the ingestion of a phosphate-containing meal. RECENT FINDINGS: Although phosphate homeostasis is controlled by a variety of hormones (such as parathyroid hormone and 1,25-dihydroxyvitamin D), peptides (the phosphatonins - fibroblast growth factor 23, secreted frizzled-related protein-4, matrix extracellular phosphoglycoprotein) and small molecules (dopamine) that regulate the efficiency of phosphate absorption in the intestine and phosphate excretion in the renal tubule, recent data suggest that postcibal changes in renal phosphate excretion following a meal containing phosphate are mediated by signals generated within the intestine that alter the efficiency of phosphate excretion in the kidney. The intestine detects luminal phosphate and signals to the kidney via the release of the mediator that increases renal phosphate excretion. SUMMARY: Such information would imply the existence of a phosphate-sensing mechanism within the intestine and the presence of intestinal factors that influence renal phosphate handling.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalCurrent opinion in nephrology and hypertension
Volume18
Issue number4
DOIs
StatePublished - Jul 1 2009

Keywords

  • Phosphate sensors
  • parathyroid hormone
  • phosphatonins
  • vitamin D

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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