Phenotypic associations of tau and ApoE in Parkinson's disease

Spiridon Papapetropoulos; Matthew J. Farrer; Jeremy T. Stone; Nicole M. Milkovic; Owen A. Ross; Linda Calvo; Donald McQuorquodale; Deborah C. Mash

doi:10.1016/j.neulet.2006.12.008

Phenotypic associations of tau and ApoE in Parkinson's disease

Spiridon Papapetropoulos, Matthew J. Farrer, Jeremy T. Stone, Nicole M. Milkovic, Owen A. Ross, Linda Calvo, Donald McQuorquodale, Deborah C. Mash

Neuroscience

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and H1H1 genotype. We also report an association between PDD and the presence of the ApoE ε4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies.

Original language	English (US)
Pages (from-to)	141-144
Number of pages	4
Journal	Neuroscience Letters
Volume	414
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2006.12.008
State	Published - Mar 6 2007

Keywords

ApoE
Association study
Dementia
Hallucinations
Phenotype
Post-mortem
Tau

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2006.12.008

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title = "Phenotypic associations of tau and ApoE in Parkinson's disease",

abstract = "Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and H1H1 genotype. We also report an association between PDD and the presence of the ApoE ε4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies.",

keywords = "ApoE, Association study, Dementia, Hallucinations, Phenotype, Post-mortem, Tau",

author = "Spiridon Papapetropoulos and Farrer, {Matthew J.} and Stone, {Jeremy T.} and Milkovic, {Nicole M.} and Ross, {Owen A.} and Linda Calvo and Donald McQuorquodale and Mash, {Deborah C.}",

note = "Funding Information: The Brain Endowment Bank{\texttrademark} is funded in part by the National Parkinson Foundation (NPF). This work was supported in part by a grant from the National Parkinson Foundation Inc. (Miami, FL). This work is supported by The Morris K. Udall Parkinson's Disease Research Center of Excellence (NINDS P50 NS40256), and NIH grants P01 AG17216 and R01 ES013941. We thank Minnie Schreiber for technical assistance. We would also like to thank the donors and their families for making these studies possible.",

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language = "English (US)",

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AU - Papapetropoulos, Spiridon

AU - Farrer, Matthew J.

AU - Stone, Jeremy T.

AU - Milkovic, Nicole M.

AU - Ross, Owen A.

AU - Calvo, Linda

AU - McQuorquodale, Donald

AU - Mash, Deborah C.

N1 - Funding Information: The Brain Endowment Bank™ is funded in part by the National Parkinson Foundation (NPF). This work was supported in part by a grant from the National Parkinson Foundation Inc. (Miami, FL). This work is supported by The Morris K. Udall Parkinson's Disease Research Center of Excellence (NINDS P50 NS40256), and NIH grants P01 AG17216 and R01 ES013941. We thank Minnie Schreiber for technical assistance. We would also like to thank the donors and their families for making these studies possible.

PY - 2007/3/6

Y1 - 2007/3/6

N2 - Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and H1H1 genotype. We also report an association between PDD and the presence of the ApoE ε4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies.

AB - Overlaps in clinical, pathological and molecular features of Parkinson's disease (PD), dementing and motor tauopathies have prompted association studies in search of common genetic risk factors that may predispose or modify this spectrum of disorders. To explore possible phenotypic implications, we studied common tau and ApoE gene polymorphisms, associated with Alzheimer's disease (AD), progressive supranuclear palsy (PSP) and PD, in a clinically and pathologically characterized cohort of PD patients and aged control subjects. Our results reveal a novel association between PD-related hallucinations and H1H1 genotype. We also report an association between PDD and the presence of the ApoE ε4 allele. Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies.

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KW - Association study

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KW - Phenotype

KW - Post-mortem

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Phenotypic associations of tau and ApoE in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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