Phenotype mapping of the multiple endocrine neoplasia type II syndrome

Gary B. Talpos, Charles E. Jackson, Joann B. Yott, Daniel L. Van Dyke

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The multiple endocrine neoplasia (MEN) IIb syndrome has been differentiated from MEN IIa by the presence of various phenotypic characteristics such as mucosal neuromas, marfanoid habitus, congenital skeletal anomalies, and prominent corneal nerves, as well as the lack of parathyroid involvement. Analysis of a kindred with some characteristics of both syndromes (including an associated chromosomal deletion) tends to unify the MEN II syndromes as a single disorder with variable expressivity. The linear map of the genetic determinants is postulated to conform with the following phenotype order: parathyroid tumors, medullary thyroid cancer, pheochromocytomas, skeletal changes, prominent corneal nerves, mucosal neuromas, and marfanoid habitus. Appreciation of this sequence can allow earlier identification and treatment of affected individuals.

Original languageEnglish (US)
Pages (from-to)650-654
Number of pages5
JournalSurgery
Volume94
Issue number4
StatePublished - 1983
Externally publishedYes

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Multiple Endocrine Neoplasia
Neuroma
Phenotype
Pheochromocytoma
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Talpos, G. B., Jackson, C. E., Yott, J. B., & Van Dyke, D. L. (1983). Phenotype mapping of the multiple endocrine neoplasia type II syndrome. Surgery, 94(4), 650-654.

Phenotype mapping of the multiple endocrine neoplasia type II syndrome. / Talpos, Gary B.; Jackson, Charles E.; Yott, Joann B.; Van Dyke, Daniel L.

In: Surgery, Vol. 94, No. 4, 1983, p. 650-654.

Research output: Contribution to journalArticle

Talpos, GB, Jackson, CE, Yott, JB & Van Dyke, DL 1983, 'Phenotype mapping of the multiple endocrine neoplasia type II syndrome', Surgery, vol. 94, no. 4, pp. 650-654.
Talpos GB, Jackson CE, Yott JB, Van Dyke DL. Phenotype mapping of the multiple endocrine neoplasia type II syndrome. Surgery. 1983;94(4):650-654.
Talpos, Gary B. ; Jackson, Charles E. ; Yott, Joann B. ; Van Dyke, Daniel L. / Phenotype mapping of the multiple endocrine neoplasia type II syndrome. In: Surgery. 1983 ; Vol. 94, No. 4. pp. 650-654.
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