TY - JOUR
T1 - Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma
T2 - Long-term results of RTOG 9402
AU - Cairncross, Gregory
AU - Wang, Meihua
AU - Shaw, Edward
AU - Jenkins, Robert
AU - Brachman, David
AU - Buckner, Jan
AU - Fink, Karen
AU - Souhami, Luis
AU - Laperriere, Normand
AU - Curran, Walter
AU - Mehta, Minesh
PY - 2013/1/20
Y1 - 2013/1/20
N2 - Purpose: Anaplastic oligodendrogliomas, pure (AO) and mixed (anaplastic oligoastrocytoma [AOA]), are chemosensitive, especially if codeleted for 1p/19q, but whether patients live longer after chemoradiotherapy is unknown Patients and Methods: Eligible patients with AO/AOA were randomly assigned to procarbazine, lomustine, and vincristine (PCV) plus radiotherapy (RT) versus RT alone. The primary end point was overall survival (OS) Results: Two hundred ninety-one eligible patients were randomly assigned: 148 to PCV plus RT and 143 to RT. For the entire cohort, there was no difference in median survival by treatment (4.6 years for PCV plus RT v 4.7 years for RT; hazard ratio [HR] = 0.79; 95% CI, 0.60 to 1.04; P =.1). Patients with codeleted tumors lived longer than those with noncodeleted tumors (PCV plus RT: 14.7 v2.6 years, HR = 0.36, 95% CI, 0.23 to 0.57, P <.001; RT: 7.3 v 2.7 years, HR = 0.40, 95% CI, 0.27 to 0.60, P <.001), and the median survival of those with codeleted tumors treated with PCV plus RT was twice that of patients receiving RT (14.7 v7.3 years; HR = 0.59; 95% CI, 0.37 to 0.95; P =.03). For those with noncodeleted tumors, there was no difference in median survival by treatment arm (2.6 v 2.7 years; HR = 0.85; 95% CI, 0.58 to 1.23; P =.39). In Cox models that ncluded codeletion status, the adjusted OS for all patients was prolonged by PCV plus RT (HR = 0.67; 95% CI, 0.50 to 0.91; P =.01) Conclusion: For the subset of patients with 1p/19q codeleted AO/AOA, PCV plus RT may be an especially effective treatment, although this observation was derived from an unplanned analysis.
AB - Purpose: Anaplastic oligodendrogliomas, pure (AO) and mixed (anaplastic oligoastrocytoma [AOA]), are chemosensitive, especially if codeleted for 1p/19q, but whether patients live longer after chemoradiotherapy is unknown Patients and Methods: Eligible patients with AO/AOA were randomly assigned to procarbazine, lomustine, and vincristine (PCV) plus radiotherapy (RT) versus RT alone. The primary end point was overall survival (OS) Results: Two hundred ninety-one eligible patients were randomly assigned: 148 to PCV plus RT and 143 to RT. For the entire cohort, there was no difference in median survival by treatment (4.6 years for PCV plus RT v 4.7 years for RT; hazard ratio [HR] = 0.79; 95% CI, 0.60 to 1.04; P =.1). Patients with codeleted tumors lived longer than those with noncodeleted tumors (PCV plus RT: 14.7 v2.6 years, HR = 0.36, 95% CI, 0.23 to 0.57, P <.001; RT: 7.3 v 2.7 years, HR = 0.40, 95% CI, 0.27 to 0.60, P <.001), and the median survival of those with codeleted tumors treated with PCV plus RT was twice that of patients receiving RT (14.7 v7.3 years; HR = 0.59; 95% CI, 0.37 to 0.95; P =.03). For those with noncodeleted tumors, there was no difference in median survival by treatment arm (2.6 v 2.7 years; HR = 0.85; 95% CI, 0.58 to 1.23; P =.39). In Cox models that ncluded codeletion status, the adjusted OS for all patients was prolonged by PCV plus RT (HR = 0.67; 95% CI, 0.50 to 0.91; P =.01) Conclusion: For the subset of patients with 1p/19q codeleted AO/AOA, PCV plus RT may be an especially effective treatment, although this observation was derived from an unplanned analysis.
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U2 - 10.1200/JCO.2012.43.2674
DO - 10.1200/JCO.2012.43.2674
M3 - Article
C2 - 23071247
AN - SCOPUS:84873338121
SN - 0732-183X
VL - 31
SP - 337
EP - 343
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 3
ER -