Phase II trial of amonafide in central nervous system tumors: A Southwest Oncology Group Study

Sarah A. Taylor; Cathryn Rankin; Jeannette J. Townsend; Johnny B. Craig; Ralph B. Vance; Dilip L. Solank; Thomas D. Brown; Kurt Jaeckle

doi:10.1023/A:1014488922368

Phase II trial of amonafide in central nervous system tumors: A Southwest Oncology Group Study

Sarah A. Taylor, Cathryn Rankin, Jeannette J. Townsend, Johnny B. Craig, Ralph B. Vance, Dilip L. Solank, Thomas D. Brown, Kurt Jaeckle

Neurology

Research output: Contribution to journal › Article

5 Scopus citations

Abstract

Amonafide 300 mg/M² was administered intravenously on a daily × 5 schedule to 27 eligible patients with recurrent or progressive central nervous system tumors. There were no objective responses. The most common toxicities were gastrointestinal, hematologic and neurologic. Further study of amonafide in patients with central nervous system malignancies is not indicated.

Original language	English (US)
Pages (from-to)	113-115
Number of pages	3
Journal	Investigational New Drugs
Volume	20
Issue number	1
DOIs	https://doi.org/10.1023/A:1014488922368
State	Published - Apr 6 2002

Keywords

Amonafide
Central nervous system tumors

ASJC Scopus subject areas

Oncology
Pharmacology
Pharmacology (medical)

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10.1023/A:1014488922368

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Taylor, S. A., Rankin, C., Townsend, J. J., Craig, J. B., Vance, R. B., Solank, D. L., Brown, T. D., & Jaeckle, K. (2002). Phase II trial of amonafide in central nervous system tumors: A Southwest Oncology Group Study. Investigational New Drugs, 20(1), 113-115. https://doi.org/10.1023/A:1014488922368

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