Phase II trial dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282

R. K. Ramanathan, A. Cnaan, R. G. Hahn, P. P. Carbone, D. G. Haller

Research output: Contribution to journalArticle

158 Scopus citations

Abstract

Background: A phase II study of dacarbazine (DTIC), was conducted to determine the response rate, duration of response, toxicity and overall survival of patients with advanced pancreatic islet cell tumors. Patients and methods: Fifty patients with advanced pancreatic islet cell tumors, having progressive symptoms or evidence of rapidly advancing disease were entered on this study. DTIC was given by IV infusion at a dose of 850 mg/m2, over 60-90 minutes, repeated every four weeks. Results: The response rate was 33% in 42 patients who had measurable tumor, and 34% in the 50 patients (90% confidence interval (90% CI): 23%-47%). The majority of the responses were seen in patients without prior chemotherapy. Median overall survival was 19.3 months. There were two lethal toxicities on the study, one septic shock and one myocardial infarction. Grade 4 toxicities were, hematological (5 patients), sepsis, neurological (depression and paranoid behavior) and bleeding (1 patient each). The most common toxicity was vomiting, grade 3 in 13% of patients. Conclusions: DTIC has activity in advanced previously untreated pancreatic islet cell tumors.

Original languageEnglish (US)
Pages (from-to)1139-1143
Number of pages5
JournalAnnals of Oncology
Volume12
Issue number8
DOIs
StatePublished - Aug 2001

Keywords

  • Dacarbazine
  • Islet cell tumors
  • Pancreas
  • Phase II

ASJC Scopus subject areas

  • Hematology
  • Oncology

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