Phase II study of Didemnin B in central nervous system tumors: A Southwest Oncology Group study

Sarah A. Taylor, Dorothy J. Giroux, Kurt A. Jaeckle, Timothy J. Panella, Shaker R. Dakhil, S. Clifford Schold

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Didemnin B 6.3 mg/m2 was administered intravenously to 48 patients with recurrent or progressive central nervous system tumors. One patient of 39 (2.9%, 95% confidence limits 0.1 to 13.5) eligible patients had a confirmed partial response utilizing standard solid tumor criteria which lasted 14 months. Toxicity was significant. Nausea and vomiting and lethargy were the most frequent toxicities, but multiple severe toxicities were seen. Further investigation of Didemnin B at this dose is not warranted in patients with central nervous system malignancies.

Original languageEnglish (US)
Pages (from-to)331-332
Number of pages2
JournalInvestigational New Drugs
Volume16
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

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didemnins
Central Nervous System Neoplasms
Lethargy
Nausea
Vomiting
Neoplasms
Central Nervous System

Keywords

  • Central nervous system tumors
  • Didemnin B

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Taylor, S. A., Giroux, D. J., Jaeckle, K. A., Panella, T. J., Dakhil, S. R., & Schold, S. C. (1998). Phase II study of Didemnin B in central nervous system tumors: A Southwest Oncology Group study. Investigational New Drugs, 16(4), 331-332. https://doi.org/10.1023/A:1006273214056

Phase II study of Didemnin B in central nervous system tumors : A Southwest Oncology Group study. / Taylor, Sarah A.; Giroux, Dorothy J.; Jaeckle, Kurt A.; Panella, Timothy J.; Dakhil, Shaker R.; Schold, S. Clifford.

In: Investigational New Drugs, Vol. 16, No. 4, 1998, p. 331-332.

Research output: Contribution to journalArticle

Taylor, SA, Giroux, DJ, Jaeckle, KA, Panella, TJ, Dakhil, SR & Schold, SC 1998, 'Phase II study of Didemnin B in central nervous system tumors: A Southwest Oncology Group study', Investigational New Drugs, vol. 16, no. 4, pp. 331-332. https://doi.org/10.1023/A:1006273214056
Taylor, Sarah A. ; Giroux, Dorothy J. ; Jaeckle, Kurt A. ; Panella, Timothy J. ; Dakhil, Shaker R. ; Schold, S. Clifford. / Phase II study of Didemnin B in central nervous system tumors : A Southwest Oncology Group study. In: Investigational New Drugs. 1998 ; Vol. 16, No. 4. pp. 331-332.
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