Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor

Terrence L. Cascino; Michael H. Veeder; Jan C. Buckner; Judith R. O'Fallon; Martin Wiesenfeld; Ralph Levitt; Richard M. Goldberg; Steven A. Kuross; Roscoe F. Morton; Bernd W. Scheithauer

doi:10.1007/BF00177275

Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor

Terrence L. Cascino, Michael H. Veeder, Jan C. Buckner, Judith R. O'Fallon, Martin Wiesenfeld, Ralph Levitt, Richard M. Goldberg, Steven A. Kuross, Roscoe F. Morton, Bernd W. Scheithauer

Medical Oncology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.

Original language	English (US)
Pages (from-to)	243-246
Number of pages	4
Journal	Journal of neuro-oncology
Volume	30
Issue number	3
DOIs	https://doi.org/10.1007/BF00177275
State	Published - 1996

Keywords

5-fluorouracil
Astrocytoma
Leucovorin
Oligodendroglioma
Radiation therapy
Recurrent glioma

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/BF00177275

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title = "Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor",

abstract = "Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.",

keywords = "5-fluorouracil, Astrocytoma, Leucovorin, Oligodendroglioma, Radiation therapy, Recurrent glioma",

author = "Cascino, {Terrence L.} and Veeder, {Michael H.} and Buckner, {Jan C.} and O'Fallon, {Judith R.} and Martin Wiesenfeld and Ralph Levitt and Goldberg, {Richard M.} and Kuross, {Steven A.} and Morton, {Roscoe F.} and Scheithauer, {Bernd W.}",

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doi = "10.1007/BF00177275",

language = "English (US)",

volume = "30",

pages = "243--246",

journal = "Journal of neuro-oncology",

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T1 - Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor

AU - Cascino, Terrence L.

AU - Veeder, Michael H.

AU - Buckner, Jan C.

AU - O'Fallon, Judith R.

AU - Wiesenfeld, Martin

AU - Levitt, Ralph

AU - Goldberg, Richard M.

AU - Kuross, Steven A.

AU - Morton, Roscoe F.

AU - Scheithauer, Bernd W.

PY - 1996

Y1 - 1996

N2 - Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.

AB - Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin. There were three responses seen. Toxicity consisted of stomatitis, diarrhea, and hematological suppression. 5-fluorouracil and leucovorin would appear to be minimally effective in recurrent brain tumors.

KW - 5-fluorouracil

KW - Astrocytoma

KW - Leucovorin

KW - Oligodendroglioma

KW - Radiation therapy

KW - Recurrent glioma

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IS - 3

ER -

Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor

Abstract

Keywords

ASJC Scopus subject areas

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