Phase II assessment of recombinant leukocyte A interferon with difluoromethylornithine in disseminated malignant melanoma

E. T. Creagan; H. J. Long; D. L. Ahmann; D. J. Schaid

doi:10.1097/00000421-199006000-00008

Phase II assessment of recombinant leukocyte A interferon with difluoromethylornithine in disseminated malignant melanoma

E. T. Creagan, H. J. Long, D. L. Ahmann, D. J. Schaid

Quantitative Health Sciences

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Abstract

Sixteen patients with advanced melanoma received IFN-α2A, 36 x 10⁶ U/m² i.m., on days 3-7 with 2.25 g/m² DFMO p.o. on days 1-7. We observed no objective regressions. Median time to progression was 1.2 months with a median survival of 5.2 months. A flu-type syndrome was the predominant sequela. From the dose and schedule that we utilized, this regimen holds little promise against disseminated malignant melanoma.

Original language	English (US)
Pages (from-to)	218-220
Number of pages	3
Journal	American Journal of Clinical Oncology: Cancer Clinical Trials
Volume	13
Issue number	3
DOIs	https://doi.org/10.1097/00000421-199006000-00008
State	Published - 1990

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "Sixteen patients with advanced melanoma received IFN-α2A, 36 x 106 U/m2 i.m., on days 3-7 with 2.25 g/m2 DFMO p.o. on days 1-7. We observed no objective regressions. Median time to progression was 1.2 months with a median survival of 5.2 months. A flu-type syndrome was the predominant sequela. From the dose and schedule that we utilized, this regimen holds little promise against disseminated malignant melanoma.",

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AU - Ahmann, D. L.

AU - Schaid, D. J.

PY - 1990

Y1 - 1990

N2 - Sixteen patients with advanced melanoma received IFN-α2A, 36 x 106 U/m2 i.m., on days 3-7 with 2.25 g/m2 DFMO p.o. on days 1-7. We observed no objective regressions. Median time to progression was 1.2 months with a median survival of 5.2 months. A flu-type syndrome was the predominant sequela. From the dose and schedule that we utilized, this regimen holds little promise against disseminated malignant melanoma.

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Phase II assessment of recombinant leukocyte A interferon with difluoromethylornithine in disseminated malignant melanoma

Abstract

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