TY - JOUR
T1 - Phase i study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies
AU - Schenk, Erin
AU - Hendrickson, Andrea E.Wahner
AU - Northfelt, Donald
AU - Toft, David O.
AU - Ames, Matthew M.
AU - Menefee, Michael
AU - Satele, Daniel
AU - Qin, Rui
AU - Erlichman, Charles
PY - 2013/10
Y1 - 2013/10
N2 - Purpose To determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of tanespimycin when given in combination with bortezomib. Experimental design Phase I dose-escalating trial using a standard cohort "3+3" design performed in patients with advanced solid tumors. Patients were given tanespimycin and bortezomib twice weekly for 2 weeks in a 3 week cycle (days 1, 4, 8, 11 every 21 days). Results Seventeen patients were enrolled in this study, fifteen were evaluable for toxicity, and nine patients were evaluable for tumor response. The MTD was 250 mg/m2 of tanespimycin and 1.0 mg/m2 of bortezomib when used in combination. DLTs of abdominal pain (13 %), complete atrioventricular block (7 %), fatigue (7 %), encephalopathy (7 %), anorexia (7 %), hyponatremia (7 %), hypoxia (7 %), and acidosis (7 %) were observed. There were no objective responses. One patient had stable disease. Conclusions The recommended phase II dose for twice weekly 17-AAG and PS341 are 250 mg/m2 and 1.0 mg/m2, respectively, on days 1, 4, 8 and 11 of a 21 day cycle.
AB - Purpose To determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of tanespimycin when given in combination with bortezomib. Experimental design Phase I dose-escalating trial using a standard cohort "3+3" design performed in patients with advanced solid tumors. Patients were given tanespimycin and bortezomib twice weekly for 2 weeks in a 3 week cycle (days 1, 4, 8, 11 every 21 days). Results Seventeen patients were enrolled in this study, fifteen were evaluable for toxicity, and nine patients were evaluable for tumor response. The MTD was 250 mg/m2 of tanespimycin and 1.0 mg/m2 of bortezomib when used in combination. DLTs of abdominal pain (13 %), complete atrioventricular block (7 %), fatigue (7 %), encephalopathy (7 %), anorexia (7 %), hyponatremia (7 %), hypoxia (7 %), and acidosis (7 %) were observed. There were no objective responses. One patient had stable disease. Conclusions The recommended phase II dose for twice weekly 17-AAG and PS341 are 250 mg/m2 and 1.0 mg/m2, respectively, on days 1, 4, 8 and 11 of a 21 day cycle.
KW - Bortezomib
KW - Phase I Trials
KW - Solid tumors
KW - Tanespimycin
UR - http://www.scopus.com/inward/record.url?scp=84884819765&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884819765&partnerID=8YFLogxK
U2 - 10.1007/s10637-013-9946-7
DO - 10.1007/s10637-013-9946-7
M3 - Article
C2 - 23543109
AN - SCOPUS:84884819765
SN - 0167-6997
VL - 31
SP - 1251
EP - 1256
JO - Investigational New Drugs
JF - Investigational New Drugs
IS - 5
ER -