Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas

Emad Elquza; Hani M. Babiker; Krisha J. Howell; Andrew I. Kovoor; Thomas David Brown; Hitendra Patel; Steven A. Malangone; Mitesh J. Borad; Tomislav Dragovich

doi:10.3109/07357907.2015.1108426

Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas

Emad Elquza, Hani M. Babiker, Krisha J. Howell, Andrew I. Kovoor, Thomas David Brown, Hitendra Patel, Steven A. Malangone, Mitesh J. Borad, Tomislav Dragovich

Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

ABSTRACT: Purpose: To establish the maximum tolerated dose (MTD) and safety profile of bi-weekly Pemetrexed (PEM) when combined with weekly cisplatin (CDDP) and standard dose external beam radiation (EBRT) in patients with locally advanced or metastatic esophageal and gastroesophageal junction (GEJ) carcinomas. Methods: We conducted an open label, single institution, phase I dose escalation study designed to evaluate up to 15–35 patients with advanced or metastatic esophageal and GEJ carcinomas. Results: 10 patients were treated with bi-weekly PEM, weekly CDDP, and EBRT. The MTD of bi-weekly PEM was determined to be 500 mg/m².

Original language	English (US)
Pages (from-to)	57-63
Number of pages	7
Journal	Cancer Investigation
Volume	34
Issue number	2
DOIs	https://doi.org/10.3109/07357907.2015.1108426
State	Published - Feb 7 2016

Keywords

Pemetrexed
cisplatin
gastroesophageal carcinoma
radiation

ASJC Scopus subject areas

Oncology
Cancer Research

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Elquza, E., Babiker, H. M., Howell, K. J., Kovoor, A. I., Brown, T. D., Patel, H., Malangone, S. A., Borad, M. J., & Dragovich, T. (2016). Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas. Cancer Investigation, 34(2), 57-63. https://doi.org/10.3109/07357907.2015.1108426

Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas. / Elquza, Emad; Babiker, Hani M.; Howell, Krisha J.; Kovoor, Andrew I.; Brown, Thomas David; Patel, Hitendra; Malangone, Steven A.; Borad, Mitesh J.; Dragovich, Tomislav.

In: Cancer Investigation, Vol. 34, No. 2, 07.02.2016, p. 57-63.

Research output: Contribution to journal › Article › peer-review

Elquza, E, Babiker, HM, Howell, KJ, Kovoor, AI, Brown, TD, Patel, H, Malangone, SA, Borad, MJ & Dragovich, T 2016, 'Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas', Cancer Investigation, vol. 34, no. 2, pp. 57-63. https://doi.org/10.3109/07357907.2015.1108426

Elquza, Emad ; Babiker, Hani M. ; Howell, Krisha J. ; Kovoor, Andrew I. ; Brown, Thomas David ; Patel, Hitendra ; Malangone, Steven A. ; Borad, Mitesh J. ; Dragovich, Tomislav. / Phase I Study of Concomitant Pemetrexed and Cisplatin Plus External Beam Radiation Therapy in Patients with Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Carcinomas. In: Cancer Investigation. 2016 ; Vol. 34, No. 2. pp. 57-63.

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abstract = "ABSTRACT: Purpose: To establish the maximum tolerated dose (MTD) and safety profile of bi-weekly Pemetrexed (PEM) when combined with weekly cisplatin (CDDP) and standard dose external beam radiation (EBRT) in patients with locally advanced or metastatic esophageal and gastroesophageal junction (GEJ) carcinomas. Methods: We conducted an open label, single institution, phase I dose escalation study designed to evaluate up to 15–35 patients with advanced or metastatic esophageal and GEJ carcinomas. Results: 10 patients were treated with bi-weekly PEM, weekly CDDP, and EBRT. The MTD of bi-weekly PEM was determined to be 500 mg/m2.",

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author = "Emad Elquza and Babiker, {Hani M.} and Howell, {Krisha J.} and Kovoor, {Andrew I.} and Brown, {Thomas David} and Hitendra Patel and Malangone, {Steven A.} and Borad, {Mitesh J.} and Tomislav Dragovich",

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AU - Babiker, Hani M.

AU - Howell, Krisha J.

AU - Kovoor, Andrew I.

AU - Brown, Thomas David

AU - Patel, Hitendra

AU - Malangone, Steven A.

AU - Borad, Mitesh J.

AU - Dragovich, Tomislav

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AB - ABSTRACT: Purpose: To establish the maximum tolerated dose (MTD) and safety profile of bi-weekly Pemetrexed (PEM) when combined with weekly cisplatin (CDDP) and standard dose external beam radiation (EBRT) in patients with locally advanced or metastatic esophageal and gastroesophageal junction (GEJ) carcinomas. Methods: We conducted an open label, single institution, phase I dose escalation study designed to evaluate up to 15–35 patients with advanced or metastatic esophageal and GEJ carcinomas. Results: 10 patients were treated with bi-weekly PEM, weekly CDDP, and EBRT. The MTD of bi-weekly PEM was determined to be 500 mg/m2.

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