Phase-contrast MRI-based elastography technique detects early hypertensive changes in Ex vivo porcine aortic wall

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Abstract

Purpose: To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique. Materials and Methods: Female domestic pigs were randomized to a normal control group (N; n = 5) or a renovascular hypertension group (HT; n = 5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 ± 12 vs. 115 ± 11 mmHg, P £ 0.05). The animals were euthanized after 3 months ofhypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique. Results: The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 ± 0.080 vs. 0.419 ± 0.026, P < 0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elas-tin staining showed no difference. Conclusion: The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume29
Issue number3
DOIs
StatePublished - Mar 2009

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Elasticity Imaging Techniques
Swine
Magnetic Resonance Imaging
Control Groups
Hypertension
Aorta
Staining and Labeling
Sus scrofa
Renovascular Hypertension
Vascular Stiffness
Tin
Elastic Modulus
Abdominal Aorta
Serotonin
Arterial Pressure
Collagen

Keywords

  • Aorta
  • Elastography
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Phase-contrast MRI-based elastography technique detects early hypertensive changes in Ex vivo porcine aortic wall",
abstract = "Purpose: To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique. Materials and Methods: Female domestic pigs were randomized to a normal control group (N; n = 5) or a renovascular hypertension group (HT; n = 5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 ± 12 vs. 115 ± 11 mmHg, P £ 0.05). The animals were euthanized after 3 months ofhypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique. Results: The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 ± 0.080 vs. 0.419 ± 0.026, P < 0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elas-tin staining showed no difference. Conclusion: The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.",
keywords = "Aorta, Elastography, MRI",
author = "Woodrum, {David A} and Joerg Herrmann and Amir Lerman and Romano, {Anthony J.} and Lerman, {Lilach O} and Ehman, {Richard Lorne}",
year = "2009",
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AU - Herrmann, Joerg

AU - Lerman, Amir

AU - Romano, Anthony J.

AU - Lerman, Lilach O

AU - Ehman, Richard Lorne

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N2 - Purpose: To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique. Materials and Methods: Female domestic pigs were randomized to a normal control group (N; n = 5) or a renovascular hypertension group (HT; n = 5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 ± 12 vs. 115 ± 11 mmHg, P £ 0.05). The animals were euthanized after 3 months ofhypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique. Results: The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 ± 0.080 vs. 0.419 ± 0.026, P < 0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elas-tin staining showed no difference. Conclusion: The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.

AB - Purpose: To measure the elastic properties of ex vivo porcine aortas in control and hypertensive groups using a phase contrast magnetic resonance imaging (MRI)-based elastography technique. Materials and Methods: Female domestic pigs were randomized to a normal control group (N; n = 5) or a renovascular hypertension group (HT; n = 5) for the duration of 3 months. Mean arterial pressure was significantly higher in the hypertension group than in the control group (173 ± 12 vs. 115 ± 11 mmHg, P £ 0.05). The animals were euthanized after 3 months ofhypertension and abdominal aortas harvested. The ex vivo aortic samples were then examined using a phase-contrast MRI-based elastography technique. Results: The Young's modulus-wall thickness product, a reflection of vascular stiffness, was significantly higher in the hypertension group than in the control group (0.571 ± 0.080 vs. 0.419 ± 0.026, P < 0.05). Histological analysis and staining confirmed increased intima-media thickness and collagen content in the hypertensive aorta, while elas-tin staining showed no difference. Conclusion: The current study shows that MR elastography offers a method to study the physiologic changes in the arterial wall secondary to early hypertension.

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