Pharmacological prophylaxis of venous thromboembolism during acute phase of spontaneous intracerebral hemorrhage: What do we know about risks and benefits?

Luca Masotti, Daniel Agustin Godoy, Mario Di Napoli, Alejandro A. Rabinstein, Maurizio Paciaroni, Walter Ageno

Research output: Contribution to journalReview article

9 Scopus citations


Spontaneous intracerebral hemorrhage (sICH) represents a devastating clinical event with high mortality and morbidity rates. Only few patients with sICH are treated with neurosurgical evacuation of the hematoma, and the majority of them need only a good conservative medical approach. The goal of medical treatment is to avoid secondary neurological and systemic complications. Venous thromboembolism (VTE) represents one of the most feared complications of sICH, and it is a potential cause of death. The balance between the benefit of VTE prevention and the risk of hematoma enlargement and/or rebleeding with the use of pharmacologic thromboprophylaxis remains controversial because of the lack of consistent evidences in the literature. The efficacy of mechanical prophylaxis is also uncertain. Consequently, until now there are no clear guidelines and scientific evidences available for physicians in this field. The aim of this review is to analyze the available literature and guidelines about pharmacological VTE prophylaxis in patients with nonsurgical sICH.

Original languageEnglish (US)
Pages (from-to)393-402
Number of pages10
JournalClinical and Applied Thrombosis/Hemostasis
Issue number4
StatePublished - Jul 1 2012



  • deep vein thrombosis
  • intracerebral hemorrhage
  • low molecular weight heparin
  • prophylaxis
  • pulmonary embolism
  • therapy
  • unfractioned heparin

ASJC Scopus subject areas

  • Hematology

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