TY - JOUR
T1 - Pharmacological modulation of rectal tone alters perception of distention in humans
AU - Malcolm, Allison
AU - Phillips, Sidney F.
AU - Camilleri, Michael
AU - Hanson, Russell B.
PY - 1997/11
Y1 - 1997/11
N2 - Objective: Drugs can alter perception of balloon distention of the GI tract. It has been proposed that the mechanism by which this occurs is through effects on visceral afferent pathways. Our hypothesis was that modulation of rectal tone will also influence the perception of rectal balloon distention. Methods: Fasting and postprandial rectal tone, compliance, and perception of rectal distention were measured in 25 healthy subjects, using a five-armed, parallel, single-blinded study design. Each subject received either glucagon, nitroglycerin, clonidine, yohimbine, or saline. Results: Rectal tone, but not compliance, influenced perception as measured by balloon distention of the rectum (r = 0.6, p = 0.002). Glucagon, nitroglycerin, and clonidine reduced and yohimbine increased fasting tone compared with saline. Compliance and postprandial tone were similar in all groups. Yohimbine increased rectal perception of distention. Conclusions: Tone is one of the factors that influences the sensory perception of balloon distention in the human rectum. α2-Adrenergic agents, a nitric oxide donor, and glucagon altered fasting rectal tone, but postprandial tone was similar after administration of each agent.
AB - Objective: Drugs can alter perception of balloon distention of the GI tract. It has been proposed that the mechanism by which this occurs is through effects on visceral afferent pathways. Our hypothesis was that modulation of rectal tone will also influence the perception of rectal balloon distention. Methods: Fasting and postprandial rectal tone, compliance, and perception of rectal distention were measured in 25 healthy subjects, using a five-armed, parallel, single-blinded study design. Each subject received either glucagon, nitroglycerin, clonidine, yohimbine, or saline. Results: Rectal tone, but not compliance, influenced perception as measured by balloon distention of the rectum (r = 0.6, p = 0.002). Glucagon, nitroglycerin, and clonidine reduced and yohimbine increased fasting tone compared with saline. Compliance and postprandial tone were similar in all groups. Yohimbine increased rectal perception of distention. Conclusions: Tone is one of the factors that influences the sensory perception of balloon distention in the human rectum. α2-Adrenergic agents, a nitric oxide donor, and glucagon altered fasting rectal tone, but postprandial tone was similar after administration of each agent.
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M3 - Article
C2 - 9362196
AN - SCOPUS:0030725011
SN - 0002-9270
VL - 92
SP - 2073
EP - 2079
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 11
ER -