Pharmacological modulation of rectal tone alters perception of distention in humans

Allison Malcolm, Sidney F. Phillips, Michael Camilleri, Russell B. Hanson

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Objective: Drugs can alter perception of balloon distention of the GI tract. It has been proposed that the mechanism by which this occurs is through effects on visceral afferent pathways. Our hypothesis was that modulation of rectal tone will also influence the perception of rectal balloon distention. Methods: Fasting and postprandial rectal tone, compliance, and perception of rectal distention were measured in 25 healthy subjects, using a five-armed, parallel, single-blinded study design. Each subject received either glucagon, nitroglycerin, clonidine, yohimbine, or saline. Results: Rectal tone, but not compliance, influenced perception as measured by balloon distention of the rectum (r = 0.6, p = 0.002). Glucagon, nitroglycerin, and clonidine reduced and yohimbine increased fasting tone compared with saline. Compliance and postprandial tone were similar in all groups. Yohimbine increased rectal perception of distention. Conclusions: Tone is one of the factors that influences the sensory perception of balloon distention in the human rectum. α2-Adrenergic agents, a nitric oxide donor, and glucagon altered fasting rectal tone, but postprandial tone was similar after administration of each agent.

Original languageEnglish (US)
Pages (from-to)2073-2079
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume92
Issue number11
StatePublished - Nov 1997

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Pharmacology
Yohimbine
Glucagon
Compliance
Fasting
Nitroglycerin
Clonidine
Rectum
Visceral Afferents
Afferent Pathways
Nitric Oxide Donors
Adrenergic Agents
Gastrointestinal Tract
Healthy Volunteers
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pharmacological modulation of rectal tone alters perception of distention in humans. / Malcolm, Allison; Phillips, Sidney F.; Camilleri, Michael; Hanson, Russell B.

In: American Journal of Gastroenterology, Vol. 92, No. 11, 11.1997, p. 2073-2079.

Research output: Contribution to journalArticle

Malcolm, Allison ; Phillips, Sidney F. ; Camilleri, Michael ; Hanson, Russell B. / Pharmacological modulation of rectal tone alters perception of distention in humans. In: American Journal of Gastroenterology. 1997 ; Vol. 92, No. 11. pp. 2073-2079.
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