Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline Update

Dolores Shoback, Clifford J. Rosen, Dennis M. Black, Angela M. Cheung, M. Hassan Murad, Richard Eastell

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Objective: The objective is to provide an update of the 2019 Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline for the pharmacological management of osteoporosis in postmenopausal women using romosozumab. Conclusions: We reviewed findings from the meta-analysis and primary clinical trials assessing the efficacy of romosozumab, a monoclonal antibody targeting sclerostin, for the prevention of fractures and concluded that this agent can be considered a treatment option for postmenopausal women at very high risk for osteoporotic fracture. The romosozumab label has a boxed warning, recommending careful consideration by the treating clinician as to cardiovascular risk profile in the individual woman who might receive this agent, since clinical trial data from an active comparator study show an imbalance in serious cardiovascular adverse events between romosozumab and alendronate.

Original languageEnglish (US)
Article numberdgaa048
JournalJournal of Clinical Endocrinology and Metabolism
Volume105
Issue number3
DOIs
StatePublished - Jan 8 2020

Keywords

  • cardiovascular
  • guideline
  • osteoporosis
  • postmenopausal women
  • romosozumab
  • sclerostin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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