Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure

P. Sandroni, E. E. Benarroch, Phillip Anson Low

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

The arterial blood pressure (BP) components of the Valsalva maneuver (VM) were analyzed to ascertain whether they could be used as an index of adrenergic regulation of the circulation. We studied a control and three age- and sex-matched patient groups. Sympathetic adrenergic failure was graded on the basis of the degree of systolic BP (SBP) reduction during tilt: orthostatic hypotension (OH; SBP >30 mmHg), borderline OH (BOH; 30< SBP >10 mmHg), and sympathetic sudomotor failure (SSF). Controls exhibited a biphasic phase II, consisting of a modest decrement (early phase II) followed by a rise in BP (late phase II; II1) above resting values. All the patient groups including SSF exhibited a significant reduction in II1. An excessive BP fall in phase II and an absent phase IV overshoot were observed in the OH group. BOH and, to a lesser extent, SSF groups showed a significant reduction in phase IV overshoot. We conclude that BP changes during VM will detect adrenergic vasoconstrictor failure with greater sensitivity than orthostatic BP recordings.

Original languageEnglish (US)
Pages (from-to)1563-1567
Number of pages5
JournalJournal of Applied Physiology
Volume71
Issue number4
StatePublished - 1991

Fingerprint

Valsalva Maneuver
Adrenergic Agents
Dissection
Pharmacology
Blood Pressure
Orthostatic Hypotension
Vasoconstrictor Agents
Arterial Pressure
Research Design

Keywords

  • orthostatic hypotension
  • sudomotor failure
  • systolic blood pressure

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure. / Sandroni, P.; Benarroch, E. E.; Low, Phillip Anson.

In: Journal of Applied Physiology, Vol. 71, No. 4, 1991, p. 1563-1567.

Research output: Contribution to journalArticle

@article{1d32410f466144959050010a9c7bd330,
title = "Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure",
abstract = "The arterial blood pressure (BP) components of the Valsalva maneuver (VM) were analyzed to ascertain whether they could be used as an index of adrenergic regulation of the circulation. We studied a control and three age- and sex-matched patient groups. Sympathetic adrenergic failure was graded on the basis of the degree of systolic BP (SBP) reduction during tilt: orthostatic hypotension (OH; SBP >30 mmHg), borderline OH (BOH; 30< SBP >10 mmHg), and sympathetic sudomotor failure (SSF). Controls exhibited a biphasic phase II, consisting of a modest decrement (early phase II) followed by a rise in BP (late phase II; II1) above resting values. All the patient groups including SSF exhibited a significant reduction in II1. An excessive BP fall in phase II and an absent phase IV overshoot were observed in the OH group. BOH and, to a lesser extent, SSF groups showed a significant reduction in phase IV overshoot. We conclude that BP changes during VM will detect adrenergic vasoconstrictor failure with greater sensitivity than orthostatic BP recordings.",
keywords = "orthostatic hypotension, sudomotor failure, systolic blood pressure",
author = "P. Sandroni and Benarroch, {E. E.} and Low, {Phillip Anson}",
year = "1991",
language = "English (US)",
volume = "71",
pages = "1563--1567",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "4",

}

TY - JOUR

T1 - Pharmacological dissection of components of the Valsalva maneuver in adrenergic failure

AU - Sandroni, P.

AU - Benarroch, E. E.

AU - Low, Phillip Anson

PY - 1991

Y1 - 1991

N2 - The arterial blood pressure (BP) components of the Valsalva maneuver (VM) were analyzed to ascertain whether they could be used as an index of adrenergic regulation of the circulation. We studied a control and three age- and sex-matched patient groups. Sympathetic adrenergic failure was graded on the basis of the degree of systolic BP (SBP) reduction during tilt: orthostatic hypotension (OH; SBP >30 mmHg), borderline OH (BOH; 30< SBP >10 mmHg), and sympathetic sudomotor failure (SSF). Controls exhibited a biphasic phase II, consisting of a modest decrement (early phase II) followed by a rise in BP (late phase II; II1) above resting values. All the patient groups including SSF exhibited a significant reduction in II1. An excessive BP fall in phase II and an absent phase IV overshoot were observed in the OH group. BOH and, to a lesser extent, SSF groups showed a significant reduction in phase IV overshoot. We conclude that BP changes during VM will detect adrenergic vasoconstrictor failure with greater sensitivity than orthostatic BP recordings.

AB - The arterial blood pressure (BP) components of the Valsalva maneuver (VM) were analyzed to ascertain whether they could be used as an index of adrenergic regulation of the circulation. We studied a control and three age- and sex-matched patient groups. Sympathetic adrenergic failure was graded on the basis of the degree of systolic BP (SBP) reduction during tilt: orthostatic hypotension (OH; SBP >30 mmHg), borderline OH (BOH; 30< SBP >10 mmHg), and sympathetic sudomotor failure (SSF). Controls exhibited a biphasic phase II, consisting of a modest decrement (early phase II) followed by a rise in BP (late phase II; II1) above resting values. All the patient groups including SSF exhibited a significant reduction in II1. An excessive BP fall in phase II and an absent phase IV overshoot were observed in the OH group. BOH and, to a lesser extent, SSF groups showed a significant reduction in phase IV overshoot. We conclude that BP changes during VM will detect adrenergic vasoconstrictor failure with greater sensitivity than orthostatic BP recordings.

KW - orthostatic hypotension

KW - sudomotor failure

KW - systolic blood pressure

UR - http://www.scopus.com/inward/record.url?scp=0025939763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025939763&partnerID=8YFLogxK

M3 - Article

C2 - 1757382

AN - SCOPUS:0025939763

VL - 71

SP - 1563

EP - 1567

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -