Pharmacological and Pharmacokinetic Aspects of Functional Gastrointestinal Disorders

Michael Camilleri, Lionel Bueno, Fabrizio de Ponti, Jean Fioramonti, R. Bruce Lydiard, Jan Tack

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Medications are commonly used for the treatment of patients with functional gastrointestinal disorders. The general goal of this report is to review the pharmacokinetics and pharmacology of medications used in functional gastrointestinal disorders. Methods included literature review, consensus evaluation of the evidence for each topic assigned originally to 1 or 2 authors, and broader review at a harmonization session as part of the Rome III process. This report reviews the animal models that have been validated for the study of effects of pharmacologic agents on sensation and motility; the preclinical pharmacology, pharmacokinetics, and toxicology usually required for introduction of novel therapeutic agents; the biomarkers validated for studies of sensation and motility end points with experimental medications in humans; the pharmacogenomics applied to these medications and disorders; and the pharmacology of agents that are applied or have potential for treatment of functional gastrointestinal disorders, including psychopharmacologic agents. Clinician and basic investigators involved in the treatment or investigation of functional gastrointestinal disorders or disease models need to have a comprehensive understanding of a vast range of medications. It is anticipated that the interaction between investigators of basic science, basic and applied pharmacology, and clinical trials will lead to better treatment of these disorders.

Original languageEnglish (US)
Pages (from-to)1421-1434
Number of pages14
JournalGastroenterology
Volume130
Issue number5
DOIs
StatePublished - May 2006

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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