Pharmacologic, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders

Michael Camilleri, Lionel Buéno, Viola Andresen, Fabrizio De Ponti, Myung Gyu Choi, Anthony Lembo

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

This article reviews medications commonly used for the treatment of patients with functional gastrointestinal disorders. Specifically, we review the animal models that have been validated for the study of drug effects on sensation and motility; the preclinical pharmacology, pharmacokinetics, and toxicology usually required for introduction of new drugs; the biomarkers that are validated for studies of sensation and motility end points with experimental medications in humans; the pharmacogenomics applied to these medications and their relevance to the FGIDs; and the pharmacology of agents that are applied or have potential for the treatment of FGIDs, including psychopharmacologic drugs.

Original languageEnglish (US)
Pages (from-to)1319-1331e20
JournalGastroenterology
Volume150
Issue number6
DOIs
StatePublished - May 1 2016

Keywords

  • Animal Models
  • Constipation
  • Diarrhea
  • Dyspepsia
  • Pain
  • Sensation
  • Transit

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Pharmacologic, pharmacokinetic, and pharmacogenomic aspects of functional gastrointestinal disorders'. Together they form a unique fingerprint.

Cite this