TY - JOUR
T1 - Pharmacologic management of seizures in organ transplant
AU - Chabolla, David R.
AU - Wszolek, Zbigniew K.
N1 - Funding Information:
This supplement has been supported through an unrestricted grant from UCB S.A., manufacturers of levetiracetam (Keppra®).
PY - 2006/12
Y1 - 2006/12
N2 - Seizures in a transplant candidate or recipient raise complicated management issues, but there are no results from controlled drug trials to guide their pharmacologic treatment. Most seizures in the transplant population are isolated events that do not require long-term antiseizure therapy. Short-term therapy, however, can reduce seizure recurrence. This review focuses on the pharmacologic management issues associated with acute and short-term therapy of seizures in this population. Phenytoin, fosphenytoin, and phenobarbital are current first-line therapies. The interactions between immunosuppressants and these antiepileptic drugs (AEDs) are of particular importance because the latter may reduce immunosuppressant blood levels. Other, newer agents are not subject to this interaction, and further studies are needed to define their role in the management of seizures in transplant patients.
AB - Seizures in a transplant candidate or recipient raise complicated management issues, but there are no results from controlled drug trials to guide their pharmacologic treatment. Most seizures in the transplant population are isolated events that do not require long-term antiseizure therapy. Short-term therapy, however, can reduce seizure recurrence. This review focuses on the pharmacologic management issues associated with acute and short-term therapy of seizures in this population. Phenytoin, fosphenytoin, and phenobarbital are current first-line therapies. The interactions between immunosuppressants and these antiepileptic drugs (AEDs) are of particular importance because the latter may reduce immunosuppressant blood levels. Other, newer agents are not subject to this interaction, and further studies are needed to define their role in the management of seizures in transplant patients.
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U2 - 10.1212/wnl.67.12_suppl_4.s34
DO - 10.1212/wnl.67.12_suppl_4.s34
M3 - Review article
C2 - 17190920
AN - SCOPUS:33845716177
SN - 0028-3878
VL - 67
SP - S34-S38
JO - Neurology
JF - Neurology
IS - 12 SUPPL. 4
ER -