Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity

P. Toby H. Coates, Bridget L. Colvin, Katsuhiko Kaneko, Timucin Taner, Angus W. Thomson

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

There are various approaches to the enhancement of dendritic cell (DC) tolerogenicity for the promotion of cell or organ allograft survival. Both pharmacologic and biologic agents, including several commonly used immunosuppressive drugs, and specific anti-inflammatory cytokines inhibit DC maturation, whereas costimulation-blocking agents can also promote the induction of antigen-specific T-cell unresponsiveness by DC. Delivery of genes encoding molecules that subvert T-cell responses by various mechanisms, and targeting of DC migration by selective manipulation of chemokine and chemokine receptor expression, represent additional promising strategies. In this short review, the authors consider those approaches that have been used to promote the tolerogenicity of donor-derived DC in experimental models. Whereas most work to date has focused on myeloid DC, manipulation of other DC subsets may also offer potential for improving the outcome of transplantation and enhancing tolerance induction.

Original languageEnglish (US)
JournalTransplantation
Volume75
Issue number9 SUPPL.
StatePublished - May 15 2003
Externally publishedYes

Fingerprint

Genetic Engineering
Dendritic Cells
Transplantation Tolerance
T-Lymphocytes
Tissue Survival
Chemokine Receptors
Biological Factors
Myeloid Cells
Immunosuppressive Agents
Chemokines
Cell Movement
Allografts
Anti-Inflammatory Agents
Theoretical Models
Cytokines
Antigens
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Transplantation

Cite this

Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity. / Coates, P. Toby H.; Colvin, Bridget L.; Kaneko, Katsuhiko; Taner, Timucin; Thomson, Angus W.

In: Transplantation, Vol. 75, No. 9 SUPPL., 15.05.2003.

Research output: Contribution to journalArticle

Coates, P. Toby H. ; Colvin, Bridget L. ; Kaneko, Katsuhiko ; Taner, Timucin ; Thomson, Angus W. / Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity. In: Transplantation. 2003 ; Vol. 75, No. 9 SUPPL.
@article{b45ae0f97be5469d998e71189752039c,
title = "Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity",
abstract = "There are various approaches to the enhancement of dendritic cell (DC) tolerogenicity for the promotion of cell or organ allograft survival. Both pharmacologic and biologic agents, including several commonly used immunosuppressive drugs, and specific anti-inflammatory cytokines inhibit DC maturation, whereas costimulation-blocking agents can also promote the induction of antigen-specific T-cell unresponsiveness by DC. Delivery of genes encoding molecules that subvert T-cell responses by various mechanisms, and targeting of DC migration by selective manipulation of chemokine and chemokine receptor expression, represent additional promising strategies. In this short review, the authors consider those approaches that have been used to promote the tolerogenicity of donor-derived DC in experimental models. Whereas most work to date has focused on myeloid DC, manipulation of other DC subsets may also offer potential for improving the outcome of transplantation and enhancing tolerance induction.",
author = "Coates, {P. Toby H.} and Colvin, {Bridget L.} and Katsuhiko Kaneko and Timucin Taner and Thomson, {Angus W.}",
year = "2003",
month = "5",
day = "15",
language = "English (US)",
volume = "75",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "9 SUPPL.",

}

TY - JOUR

T1 - Pharmacologic, biologic, and genetic engineering approaches to potentiation of donor-derived dendritic cell tolerogenicity

AU - Coates, P. Toby H.

AU - Colvin, Bridget L.

AU - Kaneko, Katsuhiko

AU - Taner, Timucin

AU - Thomson, Angus W.

PY - 2003/5/15

Y1 - 2003/5/15

N2 - There are various approaches to the enhancement of dendritic cell (DC) tolerogenicity for the promotion of cell or organ allograft survival. Both pharmacologic and biologic agents, including several commonly used immunosuppressive drugs, and specific anti-inflammatory cytokines inhibit DC maturation, whereas costimulation-blocking agents can also promote the induction of antigen-specific T-cell unresponsiveness by DC. Delivery of genes encoding molecules that subvert T-cell responses by various mechanisms, and targeting of DC migration by selective manipulation of chemokine and chemokine receptor expression, represent additional promising strategies. In this short review, the authors consider those approaches that have been used to promote the tolerogenicity of donor-derived DC in experimental models. Whereas most work to date has focused on myeloid DC, manipulation of other DC subsets may also offer potential for improving the outcome of transplantation and enhancing tolerance induction.

AB - There are various approaches to the enhancement of dendritic cell (DC) tolerogenicity for the promotion of cell or organ allograft survival. Both pharmacologic and biologic agents, including several commonly used immunosuppressive drugs, and specific anti-inflammatory cytokines inhibit DC maturation, whereas costimulation-blocking agents can also promote the induction of antigen-specific T-cell unresponsiveness by DC. Delivery of genes encoding molecules that subvert T-cell responses by various mechanisms, and targeting of DC migration by selective manipulation of chemokine and chemokine receptor expression, represent additional promising strategies. In this short review, the authors consider those approaches that have been used to promote the tolerogenicity of donor-derived DC in experimental models. Whereas most work to date has focused on myeloid DC, manipulation of other DC subsets may also offer potential for improving the outcome of transplantation and enhancing tolerance induction.

UR - http://www.scopus.com/inward/record.url?scp=0037846483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037846483&partnerID=8YFLogxK

M3 - Article

C2 - 12819488

AN - SCOPUS:0037846483

VL - 75

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 9 SUPPL.

ER -