Pharmacokinetics of daily versus monthly vitamin D3 supplementation in non-lactating women

M. E. Meekins; S. S. Oberhelman; B. R. Lee; B. M. Gardner; S. S. Cha; R. J. Singh; J. M. Pettifor; P. R. Fischer; T. D. Thacher

doi:10.1038/ejcn.2013.278

Pharmacokinetics of daily versus monthly vitamin D₃ supplementation in non-lactating women

M. E. Meekins, S. S. Oberhelman, B. R. Lee, B. M. Gardner, S. S. Cha, R. J. Singh, J. M. Pettifor, P. R. Fischer, T. D. Thacher

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18-40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC 28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC 28 compared with the daily group (P<0.001).

Original language	English (US)
Pages (from-to)	632-634
Number of pages	3
Journal	European journal of clinical nutrition
Volume	68
Issue number	5
DOIs	https://doi.org/10.1038/ejcn.2013.278
State	Published - May 2014

Keywords

metabolism
pharmacokinetics
vitamin D
women

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

Access to Document

10.1038/ejcn.2013.278

Cite this

@article{e4c5abea176c41b88c3cf9e7d3d8de72,

title = "Pharmacokinetics of daily versus monthly vitamin D3 supplementation in non-lactating women",

abstract = "This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18-40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC 28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC 28 compared with the daily group (P<0.001).",

keywords = "metabolism, pharmacokinetics, vitamin D, women",

author = "Meekins, {M. E.} and Oberhelman, {S. S.} and Lee, {B. R.} and Gardner, {B. M.} and Cha, {S. S.} and Singh, {R. J.} and Pettifor, {J. M.} and Fischer, {P. R.} and Thacher, {T. D.}",

note = "Funding Information: This project was supported by NIH/NCRR CTSA Grant Number UL1 RR024150. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. This study was partially funded by a research grant from the Mayo Clinic Pharmacy Services Discretionary Fund.",

year = "2014",

month = may,

doi = "10.1038/ejcn.2013.278",

language = "English (US)",

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AU - Meekins, M. E.

AU - Oberhelman, S. S.

AU - Lee, B. R.

AU - Gardner, B. M.

AU - Cha, S. S.

AU - Singh, R. J.

AU - Pettifor, J. M.

AU - Fischer, P. R.

AU - Thacher, T. D.

N1 - Funding Information: This project was supported by NIH/NCRR CTSA Grant Number UL1 RR024150. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. This study was partially funded by a research grant from the Mayo Clinic Pharmacy Services Discretionary Fund.

PY - 2014/5

Y1 - 2014/5

N2 - This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18-40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC 28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC 28 compared with the daily group (P<0.001).

AB - This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18-40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC 28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC 28 compared with the daily group (P<0.001).

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