Pharmacogenomics in gastrointestinal disorders

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is anticipated that unraveling the human genome will have a direct impact on the management of specific diseases. Variations or mutations in genes involved in drug metabolism or disease pathophysiology in gastroenterology and hepatology are expected to have effect on response to therapy. The spectrum of diseases is vast. Thus, we focus this review on clinical pharmacogenetics of inflammatory bowel disease, Helicobacter pylori infections, gastroesophageal reflux disease, irritable bowel syndrome, liver transplantation, and colon cancer. Although only a few genotyping tests are used regularly in clinical practice, we anticipate that in the future there will be more routine use of many of the tests described in this review.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages395-412
Number of pages18
Volume448
DOIs
StatePublished - 2008

Publication series

NameMethods in Molecular Biology
Volume448
ISSN (Print)10643745

Keywords

  • Colon cancer
  • Functional dyspepsia
  • Functional gastrointestinal disorders
  • Gastroesophageal reflux disease
  • Helicobacter pylori infection
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Liver transplantation
  • Pharmacogenetics

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology

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  • Cite this

    Camilleri, M., & Saito, Y. A. (2008). Pharmacogenomics in gastrointestinal disorders. In Methods in Molecular Biology (Vol. 448, pp. 395-412). (Methods in Molecular Biology; Vol. 448). https://doi.org/10.1007/978-1-59745-205-2-13