Pharmacogenomics and serotonergic agents: Research observations and potential clinical practice implications

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Pharmacogenomics of serotonin are potentially relevant in research and clinical practice. There are few proven examples of the importance of pharmacogenetics of serotonin-modifying agents used in functional gastrointestinal or motility disorders. Drug metabolism is dependent on function of the cytochrome P450 enzymes, such as 2D6 and 3A4. Genetic variations in transporters and translation mechanisms have been associated with responses to treatment in irritable bowel syndrome and in obesity. Research on the impact of polymorphisms of key proteins on the pharmacokinetics and pharmacodynamics of drugs that alter serotonin-mediated signalling will assist in explaining diverse responses to those drugs and ultimately improve clinical practice, individualizing medicine.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalNeurogastroenterology and Motility
Volume19
Issue numberSUPPL.2
DOIs
StatePublished - Aug 1 2007

Keywords

  • Alosertron
  • CYP450
  • Irritable bowel
  • Pharmacogenomics
  • Serotonin
  • Tegaserod

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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