Pharmacogenetics of methylation: Relationship to drug metabolism

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Pharmacogenetics is the study of inherited variation in drug response. Genetic differences in drug metabolism are the most common causes for inherited variations in drug response or adverse reactions to medications. Methyl conjugation is an important pathway in the biotransformation of many drugs. Experiments performed during the past decade showed that individual variations in the activities of enzymes that catalyze S-methylation, O-methylation and N-methylation are under genetic control in human tissue. These inherited variations are responsible for individual differences in metabolism, effect, and toxicity of drugs that undergo methyl conjugation. The approach used to study the pharmacogenetics of methylation may also be applicable to the study of inherited variations in other pathways of drug metabolism.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalClinical Biochemistry
Volume21
Issue number4
DOIs
StatePublished - 1988

Fingerprint

Methylation
Pharmacogenetics
Metabolism
Pharmaceutical Preparations
Biotransformation
Drug-Related Side Effects and Adverse Reactions
Individuality
Toxicity
Tissue
Enzymes
Experiments

Keywords

  • catechol O-methyltransferase
  • histamine N-methyltransferase
  • methyl conjugation
  • methylation
  • pharmacogenetics
  • thiol methyltransferase
  • thiopurine methyltransferase

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Pharmacogenetics of methylation : Relationship to drug metabolism. / Weinshilboum, Richard M.

In: Clinical Biochemistry, Vol. 21, No. 4, 1988, p. 201-210.

Research output: Contribution to journalArticle

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