TY - JOUR
T1 - Pharmacogenetics of methylation
T2 - Relationship to drug metabolism
AU - Weinshilboum, Richard
N1 - Funding Information:
Supported in part by NIH grants GM 28157 and GM 35720 and by NIH contract ES 55110.
PY - 1988/8
Y1 - 1988/8
N2 - Pharmacogenetics is the study of inherited variation in drug response. Genetic differences in drug metabolism are the most common causes for inherited variations in drug response or adverse reactions to medications. Methyl conjugation is an important pathway in the biotransformation of many drugs. Experiments performed during the past decade showed that individual variations in the activities of enzymes that catalyze S-methylation, O-methylation and N-methylation are under genetic control in human tissue. These inherited variations are responsible for individual differences in metabolism, effect, and toxicity of drugs that undergo methyl conjugation. The approach used to study the pharmacogenetics of methylation may also be applicable to the study of inherited variations in other pathways of drug metabolism.
AB - Pharmacogenetics is the study of inherited variation in drug response. Genetic differences in drug metabolism are the most common causes for inherited variations in drug response or adverse reactions to medications. Methyl conjugation is an important pathway in the biotransformation of many drugs. Experiments performed during the past decade showed that individual variations in the activities of enzymes that catalyze S-methylation, O-methylation and N-methylation are under genetic control in human tissue. These inherited variations are responsible for individual differences in metabolism, effect, and toxicity of drugs that undergo methyl conjugation. The approach used to study the pharmacogenetics of methylation may also be applicable to the study of inherited variations in other pathways of drug metabolism.
KW - catechol O-methyltransferase
KW - histamine N-methyltransferase
KW - methyl conjugation
KW - methylation
KW - pharmacogenetics
KW - thiol methyltransferase
KW - thiopurine methyltransferase
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U2 - 10.1016/S0009-9120(88)80002-X
DO - 10.1016/S0009-9120(88)80002-X
M3 - Article
C2 - 3044645
AN - SCOPUS:0023712178
SN - 0009-9120
VL - 21
SP - 201
EP - 210
JO - Clinical Biochemistry
JF - Clinical Biochemistry
IS - 4
ER -