Pharmacogenetics in irritable bowel syndrome

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Irritable bowel syndrome (IBS) is a chronic disease characterized by complex interactions between genetic predisposition and the environment. Current treatments for IBS are characterized by a highly variable response. Gene variations may result from insertions or deletions, gene rearrangements, splice variants or copy number variants, or, more commonly, from substitutions in the DNA of one (single nucleotide polymorphism [SNPs]) or more than one nucleotide. The objective of this editorial is to review the potential importance of pharmacogenetics in the treatment of IBS based on current evidence.

Original languageEnglish (US)
Pages (from-to)1187-1191
Number of pages5
JournalExpert Opinion on Drug Metabolism and Toxicology
Volume11
Issue number8
DOIs
StatePublished - Aug 1 2015

Keywords

  • Biomarkers
  • irritable bowel syndrome
  • pharmacogenetics
  • pharmacogenomics

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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