Pharmacogenetics and stroke

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

Genetic variations have been shown to influence drug metabolism, risk of adverse drug events, and pharmacodynamic responses for many drugs routinely used to treat patients with stroke or at risk for stroke. Examples include clopidogrel, statins, antihypertensive medications, and coumadin. Further validation studies are needed to assess the clinical utility of selecting drugs and doses based on genetic tests. Physicians, pharmaceutical companies, regulatory agencies, and health insurers continue to grapple with how best to translate this burgeoning field into effective individualized medicine.

Original languageEnglish (US)
Pages (from-to)3641-3645
Number of pages5
JournalStroke
Volume40
Issue number11
DOIs
StatePublished - Nov 1 2009

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Keywords

  • Cerebral infarction
  • Genetics
  • Genomics
  • Ischemic stroke
  • Pharmacogenomics
  • Pharmacology
  • Prevention

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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