Fallotoksiny kak instrument dlia issledovaniia vnutrimiofibrilliarnoi reguliatsii myshechnogo sokrashcheniia.

Translated title of the contribution: Phallotoxins as an instrument for studying the intramyofibrillar regulation of muscle contraction

A. E. Bukatina, Gary C Sieck

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The contraction of myofibrils is regulated by the coordinated action of Ca2+ and myosin cross-bridges. Phallotoxins induce a variety of specific changes in myofibrillar functioning and are therefore a potentially valuable tool for muscle research. There are two greatly differing classes of drugs among phallotoxins: (1) recently discovered secophalloidin and its derivatives. The unique property of secophalloidin is muscle activation without Ca2+, possibly by direct influence on actomyosin interaction. These drugs seem to be especially useful for studying the role of cross-bridges in muscle regulation; (2) the phalloidin group, which includes the majority of phallotoxins. When binding to the phalloidin site on F-actin, they cause muscle-specific changes. In cardiac muscle they work as Ca2+ sensitizers, increasing both the maximal force and Ca2+ sensitivity. An advantage of these drugs is that the target site is known, which allows one to unravel the sequence of molecular events leading to increased contractile function. Presumably, the complex effect of phalloidin in skeletal muscle is related to the disturbance of the actin-nebulin interaction, which may help to clarify the role of nebulin in the regulation contraction.

Original languageUndefined
Pages (from-to)1086-1093
Number of pages8
JournalBiofizika
Volume48
Issue number6
StatePublished - Nov 2003

Fingerprint

Muscle Contraction
Phalloidine
Muscles
Actins
Pharmaceutical Preparations
Actomyosin
Myofibrils
Myosins
Myocardium
Skeletal Muscle
phallotoxin
Research
nebulin

ASJC Scopus subject areas

  • Biophysics

Cite this

Fallotoksiny kak instrument dlia issledovaniia vnutrimiofibrilliarnoi reguliatsii myshechnogo sokrashcheniia. / Bukatina, A. E.; Sieck, Gary C.

In: Biofizika, Vol. 48, No. 6, 11.2003, p. 1086-1093.

Research output: Contribution to journalArticle

Bukatina, A. E. ; Sieck, Gary C. / Fallotoksiny kak instrument dlia issledovaniia vnutrimiofibrilliarnoi reguliatsii myshechnogo sokrashcheniia. In: Biofizika. 2003 ; Vol. 48, No. 6. pp. 1086-1093.
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