Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee

Jeanne Palmer, Jeannine S. McCune, Miguel Angel Perales, David Marks, Joseph Bubalo, Mohamad Mohty, John R. Wingard, Angelo Paci, Moustapha Hassan, Christopher Bredeson, Joseph Pidala, Nina Shah, Paul Shaughnessy, Navneet Majhail, Jeff Schriber, Bipin N. Savani, Paul A. Carpenter

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

The Practice Guidelines Committee of the American Society of Blood or Marrow Transplantation (ASBMT) sought to develop an evidence-based review about personalizing busulfan-based conditioning. The Committee sought to grade the relevant published studies (June 1, 2008 through March 31, 2016) according to criteria set forth by the Steering Committee for Evidence Based Reviews from ASBMT. Unfortunately, the published literature was too heterogeneous and lacked adequately powered and sufficiently controlled studies for this to be feasible. Despite this observation, the continued interest in this topic led the Practice Guidelines Committee to develop a list of most frequently asked questions (FAQs) regarding personalized busulfan dosing. This “Considerations” document is a list of these FAQs and their responses, addressing topics of practical relevance to hematopoietic cell transplantation clinicians.

Original languageEnglish (US)
Pages (from-to)1915-1925
Number of pages11
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2016

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Keywords

  • Busulfan
  • Hematopoietic cell transplantation
  • Pharmacokinetics
  • Precision medicine
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Palmer, J., McCune, J. S., Perales, M. A., Marks, D., Bubalo, J., Mohty, M., Wingard, J. R., Paci, A., Hassan, M., Bredeson, C., Pidala, J., Shah, N., Shaughnessy, P., Majhail, N., Schriber, J., Savani, B. N., & Carpenter, P. A. (2016). Personalizing Busulfan-Based Conditioning: Considerations from the American Society for Blood and Marrow Transplantation Practice Guidelines Committee. Biology of Blood and Marrow Transplantation, 22(11), 1915-1925. https://doi.org/10.1016/j.bbmt.2016.07.013