Personalized therapy for metastatic melanoma: Could timing be everything?

Roxana S Dronca, Alexey A. Leontovich, Wendy K. Nevala, Svetomir Nenad Markovic

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.

Original languageEnglish (US)
Pages (from-to)1401-1406
Number of pages6
JournalFuture Oncology
Volume8
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

temozolomide
Periodicity
Melanoma
Humoral Immunity
Cellular Immunity
Immunity
Healthy Volunteers
Cytokines
Inflammation
Drug Therapy
Therapeutics

Keywords

  • biorhythms
  • cancer
  • chemotherapy
  • cytokine
  • immunity
  • infradian
  • melanoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Personalized therapy for metastatic melanoma : Could timing be everything? / Dronca, Roxana S; Leontovich, Alexey A.; Nevala, Wendy K.; Markovic, Svetomir Nenad.

In: Future Oncology, Vol. 8, No. 11, 11.2012, p. 1401-1406.

Research output: Contribution to journalArticle

Dronca, Roxana S ; Leontovich, Alexey A. ; Nevala, Wendy K. ; Markovic, Svetomir Nenad. / Personalized therapy for metastatic melanoma : Could timing be everything?. In: Future Oncology. 2012 ; Vol. 8, No. 11. pp. 1401-1406.
@article{5f88685bc72c46d186295d625f7122e5,
title = "Personalized therapy for metastatic melanoma: Could timing be everything?",
abstract = "There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.",
keywords = "biorhythms, cancer, chemotherapy, cytokine, immunity, infradian, melanoma",
author = "Dronca, {Roxana S} and Leontovich, {Alexey A.} and Nevala, {Wendy K.} and Markovic, {Svetomir Nenad}",
year = "2012",
month = "11",
doi = "10.2217/fon.12.126",
language = "English (US)",
volume = "8",
pages = "1401--1406",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "11",

}

TY - JOUR

T1 - Personalized therapy for metastatic melanoma

T2 - Could timing be everything?

AU - Dronca, Roxana S

AU - Leontovich, Alexey A.

AU - Nevala, Wendy K.

AU - Markovic, Svetomir Nenad

PY - 2012/11

Y1 - 2012/11

N2 - There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.

AB - There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.

KW - biorhythms

KW - cancer

KW - chemotherapy

KW - cytokine

KW - immunity

KW - infradian

KW - melanoma

UR - http://www.scopus.com/inward/record.url?scp=84869170306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869170306&partnerID=8YFLogxK

U2 - 10.2217/fon.12.126

DO - 10.2217/fon.12.126

M3 - Article

C2 - 23148614

AN - SCOPUS:84869170306

VL - 8

SP - 1401

EP - 1406

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 11

ER -