Abstract
There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1401-1406 |
| Number of pages | 6 |
| Journal | Future Oncology |
| Volume | 8 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2012 |
Fingerprint
Keywords
- biorhythms
- cancer
- chemotherapy
- cytokine
- immunity
- infradian
- melanoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Personalized therapy for metastatic melanoma : Could timing be everything? / Dronca, Roxana S; Leontovich, Alexey A.; Nevala, Wendy K.; Markovic, Svetomir Nenad.
In: Future Oncology, Vol. 8, No. 11, 11.2012, p. 1401-1406.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Personalized therapy for metastatic melanoma
T2 - Could timing be everything?
AU - Dronca, Roxana S
AU - Leontovich, Alexey A.
AU - Nevala, Wendy K.
AU - Markovic, Svetomir Nenad
PY - 2012/11
Y1 - 2012/11
N2 - There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.
AB - There is ample evidence that immune-related processes in humans are under temporal regulation. The circadian variation of humoral and cellular immunity is well documented and appears to be hormonally modulated via the hypothalamic-pituitary-adrenal axis. In advanced melanoma, it has recently been demonstrated that systemic immunity is repolarized toward a global state of chronic inflammation (Th2 dominance) and appears to be governed by infradian biorhythms of cytokines and immune cell subsets, which extend beyond the 24-h circadian variability reported in healthy volunteers. It is suggested that synchronizing administration of lymphodepleting chemotherapy (temozolomide) with these endogenous (individualized) immune dynamics (biorhythms) in patients with advanced/metastatic melanoma improves clinical outcomes compared with temozolomide used in a conventional 'random delivery' fashion.
KW - biorhythms
KW - cancer
KW - chemotherapy
KW - cytokine
KW - immunity
KW - infradian
KW - melanoma
UR - http://www.scopus.com/inward/record.url?scp=84869170306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869170306&partnerID=8YFLogxK
U2 - 10.2217/fon.12.126
DO - 10.2217/fon.12.126
M3 - Article
C2 - 23148614
AN - SCOPUS:84869170306
VL - 8
SP - 1401
EP - 1406
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 11
ER -