Personal sun exposure and risk of non Hodgkin lymphoma

A pooled analysis from the Interlymph Consortium

Anne Kricker, Bruce K. Armstrong, Ann Maree Hughes, Chris Goumas, Karin Ekström Smedby, Tongzhang Zheng, John J. Spinelli, Sylvia De Sanjose, Patricia Hartge, Mads Melbye, Eleanor V. Willett, Nikolaus Becker, Brian C H Chiu, James R Cerhan, Marc Maynadié, Anthony Staines, Pierluigi Cocco, Paolo Boffeta

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

In 2004-2007 4 independent case-control studies reported evidence that sun exposure might protect against NHL; a fifth, in women only, found increased risks of NHL associated with a range of sun exposure measurements. These 5 studies are the first to examine the association between personal sun exposure and NHL. We report here on the relationship between sun exposure and NHL in a pooled analysis of 10 studies participating in the International Lymphoma Epidemiology Consortium (InterLymph), including the 5 published studies. Ten case-control studies covering 8,243 cases and 9,697 controls in the USA, Europe and Australia contributed original data for participants of European origin to the pooled analysis. Four kinds of measures of self-reported personal sun exposure were assessed at interview. A two-stage estimation method was used in which study-specific odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for potential confounders including smoking and alcohol use, were obtained from unconditional logistic regression models and combined in random-effects models to obtain the pooled estimates. Risk of NHL fell significantly with the composite measure of increasing recreational sun exposure, pooled OR = 0.76 (95% CI 0.63-0.91) for the highest exposure category (p for trend 0.01). A downtrend in risk with increasing total sun exposure was not statistically significant. The protective effect of recreational sun exposure was statistically significant at 18-40 years of age and in the 10 years before diagnosis, and for B cell, but not T cell, lymphomas. Increased recreational sun exposure may protect against NHL.

Original languageEnglish (US)
Pages (from-to)144-154
Number of pages11
JournalInternational Journal of Cancer
Volume122
Issue number1
DOIs
StatePublished - Jan 1 2008

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Solar System
Non-Hodgkin's Lymphoma
Case-Control Studies
Logistic Models
Odds Ratio
Confidence Intervals
T-Cell Lymphoma
Lymphoma
Epidemiology
B-Lymphocytes
Smoking
Alcohols
Interviews

Keywords

  • Non Hodgkin lymphoma
  • Personal sun exposure
  • Pooled analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kricker, A., Armstrong, B. K., Hughes, A. M., Goumas, C., Smedby, K. E., Zheng, T., ... Boffeta, P. (2008). Personal sun exposure and risk of non Hodgkin lymphoma: A pooled analysis from the Interlymph Consortium. International Journal of Cancer, 122(1), 144-154. https://doi.org/10.1002/ijc.23003

Personal sun exposure and risk of non Hodgkin lymphoma : A pooled analysis from the Interlymph Consortium. / Kricker, Anne; Armstrong, Bruce K.; Hughes, Ann Maree; Goumas, Chris; Smedby, Karin Ekström; Zheng, Tongzhang; Spinelli, John J.; De Sanjose, Sylvia; Hartge, Patricia; Melbye, Mads; Willett, Eleanor V.; Becker, Nikolaus; Chiu, Brian C H; Cerhan, James R; Maynadié, Marc; Staines, Anthony; Cocco, Pierluigi; Boffeta, Paolo.

In: International Journal of Cancer, Vol. 122, No. 1, 01.01.2008, p. 144-154.

Research output: Contribution to journalArticle

Kricker, A, Armstrong, BK, Hughes, AM, Goumas, C, Smedby, KE, Zheng, T, Spinelli, JJ, De Sanjose, S, Hartge, P, Melbye, M, Willett, EV, Becker, N, Chiu, BCH, Cerhan, JR, Maynadié, M, Staines, A, Cocco, P & Boffeta, P 2008, 'Personal sun exposure and risk of non Hodgkin lymphoma: A pooled analysis from the Interlymph Consortium', International Journal of Cancer, vol. 122, no. 1, pp. 144-154. https://doi.org/10.1002/ijc.23003
Kricker, Anne ; Armstrong, Bruce K. ; Hughes, Ann Maree ; Goumas, Chris ; Smedby, Karin Ekström ; Zheng, Tongzhang ; Spinelli, John J. ; De Sanjose, Sylvia ; Hartge, Patricia ; Melbye, Mads ; Willett, Eleanor V. ; Becker, Nikolaus ; Chiu, Brian C H ; Cerhan, James R ; Maynadié, Marc ; Staines, Anthony ; Cocco, Pierluigi ; Boffeta, Paolo. / Personal sun exposure and risk of non Hodgkin lymphoma : A pooled analysis from the Interlymph Consortium. In: International Journal of Cancer. 2008 ; Vol. 122, No. 1. pp. 144-154.
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