Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y. Smith, Brandon R. Grossardt, Stephanie S. Faubion, Lynne T. Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal M Kantarci, Virginia M Miller

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: We investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population. Study design: In an established cohort study, we used the records-linkage system of the Rochester Epidemiology Project (REP http://www.rochesterproject.org) to identify 1653 premenopausal women who underwent bilateral oophorectomy in Olmsted County, Minnesota between 1988 and 2007 for a nonmalignant indication. Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone bilateral oophorectomy as of the index date. We used case-control analyses to investigate several characteristics associated with bilateral oophorectomy. Odds ratios and their 95% confidence intervals were adjusted for race, education, and income. Results: In the overall analyses, infertility was more common in women who underwent bilateral oophorectomy than in the controls, whereas use of oral contraceptives, a history of breast feeding, and fibrocystic breast disease were less common. The women who underwent bilateral oophorectomy weighed more than controls, had a higher body mass index and were younger at menarche. The associations were more pronounced for women who underwent the bilateral oophorectomy before age 46 years, and some associations were different for women with or without a benign ovarian indication. Reported family histories of uterine and other cancers were more common in women without a benign ovarian indication. Conclusions: We identified a number of personal, reproductive, and familial characteristics that were associated with bilateral oophorectomy over a 20-year period. Our historical findings may help inform decision-making about oophorectomy in the future.

Original languageEnglish (US)
Pages (from-to)64-77
Number of pages14
JournalMaturitas
Volume117
DOIs
StatePublished - Nov 1 2018

Fingerprint

Ovariectomy
Case-Control Studies
Population
Epidemiology
Oral Contraceptives
Education
Decision making
Fibrocystic Breast Disease
Reproductive History
Uterine Neoplasms
Menarche
Breast Feeding
Infertility
Decision Making
Body Mass Index
Cohort Studies
Odds Ratio
Confidence Intervals

Keywords

  • Bilateral oophorectomy
  • Body mass index
  • Family history
  • Oral contraceptives
  • Reproductive history
  • Smoking

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

Cite this

Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women : A population-based case-control study. / Rocca, Walter A; Gazzuola Rocca, Liliana; Smith, Carin Y.; Grossardt, Brandon R.; Faubion, Stephanie S.; Shuster, Lynne T.; Stewart, Elizabeth A; Mielke, Michelle M; Kantarci, Kejal M; Miller, Virginia M.

In: Maturitas, Vol. 117, 01.11.2018, p. 64-77.

Research output: Contribution to journalArticle

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abstract = "Objectives: We investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population. Study design: In an established cohort study, we used the records-linkage system of the Rochester Epidemiology Project (REP http://www.rochesterproject.org) to identify 1653 premenopausal women who underwent bilateral oophorectomy in Olmsted County, Minnesota between 1988 and 2007 for a nonmalignant indication. Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone bilateral oophorectomy as of the index date. We used case-control analyses to investigate several characteristics associated with bilateral oophorectomy. Odds ratios and their 95{\%} confidence intervals were adjusted for race, education, and income. Results: In the overall analyses, infertility was more common in women who underwent bilateral oophorectomy than in the controls, whereas use of oral contraceptives, a history of breast feeding, and fibrocystic breast disease were less common. The women who underwent bilateral oophorectomy weighed more than controls, had a higher body mass index and were younger at menarche. The associations were more pronounced for women who underwent the bilateral oophorectomy before age 46 years, and some associations were different for women with or without a benign ovarian indication. Reported family histories of uterine and other cancers were more common in women without a benign ovarian indication. Conclusions: We identified a number of personal, reproductive, and familial characteristics that were associated with bilateral oophorectomy over a 20-year period. Our historical findings may help inform decision-making about oophorectomy in the future.",
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T1 - Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women

T2 - A population-based case-control study

AU - Rocca, Walter A

AU - Gazzuola Rocca, Liliana

AU - Smith, Carin Y.

AU - Grossardt, Brandon R.

AU - Faubion, Stephanie S.

AU - Shuster, Lynne T.

AU - Stewart, Elizabeth A

AU - Mielke, Michelle M

AU - Kantarci, Kejal M

AU - Miller, Virginia M

PY - 2018/11/1

Y1 - 2018/11/1

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KW - Body mass index

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KW - Oral contraceptives

KW - Reproductive history

KW - Smoking

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