Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study

Walter A Rocca, Liliana Gazzuola Rocca, Carin Y. Smith, Brandon R. Grossardt, Stephanie S. Faubion, Lynne T. Shuster, Elizabeth A Stewart, Michelle M Mielke, Kejal M Kantarci, Virginia M Miller

Research output: Contribution to journalArticle

2 Scopus citations


Objectives: We investigated the association of personal, reproductive, and familial characteristics with bilateral oophorectomy performed for nonmalignant indications in a US population. Study design: In an established cohort study, we used the records-linkage system of the Rochester Epidemiology Project (REP to identify 1653 premenopausal women who underwent bilateral oophorectomy in Olmsted County, Minnesota between 1988 and 2007 for a nonmalignant indication. Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone bilateral oophorectomy as of the index date. We used case-control analyses to investigate several characteristics associated with bilateral oophorectomy. Odds ratios and their 95% confidence intervals were adjusted for race, education, and income. Results: In the overall analyses, infertility was more common in women who underwent bilateral oophorectomy than in the controls, whereas use of oral contraceptives, a history of breast feeding, and fibrocystic breast disease were less common. The women who underwent bilateral oophorectomy weighed more than controls, had a higher body mass index and were younger at menarche. The associations were more pronounced for women who underwent the bilateral oophorectomy before age 46 years, and some associations were different for women with or without a benign ovarian indication. Reported family histories of uterine and other cancers were more common in women without a benign ovarian indication. Conclusions: We identified a number of personal, reproductive, and familial characteristics that were associated with bilateral oophorectomy over a 20-year period. Our historical findings may help inform decision-making about oophorectomy in the future.

Original languageEnglish (US)
Pages (from-to)64-77
Number of pages14
StatePublished - Nov 1 2018



  • Bilateral oophorectomy
  • Body mass index
  • Family history
  • Oral contraceptives
  • Reproductive history
  • Smoking

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynecology

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