Abstract
Residual mediastinal FDG-uptake after frontline therapy for classical Hodgkin lymphoma (cHL) may constitute persistent disease or inflammatory changes. We analyzed practice patterns at two institutions to determine how often a mediastinal biopsy influenced patient management and outcome. Forty-two cases were eligible for review, mostly treated with ABVD. Twenty (group1) underwent a mediastinal biopsy and 22 did not (group2). In group1, 10/20 were positive for cHL and proceeded to salvage therapy (ST); 4/10 biopsy-negative patients were observed, and 6/10 received consolidative radiotherapy. Ten of 22 patients from group 2 were observed, 12/22 received ST. Ten of 14 observed patients remained PET-positive and 8/8 biopsies in these patients showed cHL. Deauville score (DS) 5 was associated with a positive biopsy (10/16). No overall survival difference between groups was observed. We conclude that observation and repeat a FDG-PET is reasonable for DS3-4 while for DS5, ST should be considered pending biopsy confirmation when feasible.
Original language | English (US) |
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Pages (from-to) | 318-327 |
Number of pages | 10 |
Journal | Leukemia and Lymphoma |
Volume | 61 |
Issue number | 2 |
DOIs | |
State | Published - Jan 28 2020 |
Keywords
- ABVD
- Deauville score
- FDG-PET
- Hodgkin lymphoma
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research