Persistent Hypertension and Left Ventricular Hypertrophy after Repair of Native Coarctation of Aorta in Adults

Alexander C. Egbe, William R. Miranda, Carole A. Warnes, Crystal Bonnichsen, Juan Crestanello, Jason H. Anderson, Heidi M. Connolly

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to describe procedural outcomes, hemodynamic improvement, regression of left ventricular (LV) mass hypertrophy, and cardiovascular. The primary outcomes were procedural complications, reinterventions, and hemodynamic improvement after coarctation of aorta (COA) repair. The secondary outcomes were improvement in the severity of hypertension, regression of LV mass index, and incidence of cardiovascular events (atrial fibrillation, ventricular tachycardia, heart failure hospitalization, and cardiovascular death) after COA repair. Secondary outcomes were assessed only in patients with isolated COA who had clinical and imaging follow-up at 1 year and 3 years postintervention. Of 172 patients that underwent COA repair (surgical 161; transcatheter 11), there were no procedural deaths, and all patients had residual COA gradient <20 mm Hg. Of 128 patients that met criteria for secondary outcomes assessment, 39 (36%) had a reduction in the intensity of antihypertension therapy, and cardiovascular events occurred in 16 (13%) patients. There was no significant reduction in the overall prevalence of hypertension (stage 1 and stage 2) over time (78% versus 70% versus 73%, P=0.4 at baseline, 1 year and 3 years). Postintervention hypertension (both stage 1 and 2) were independent risk factors for suboptimal left ventricular mass index regression and cardiovascular events. Persistent hypertension was common after repair of native COA in adults and was associated with suboptimal left ventricular mass index regression and cardiovascular events. These results suggest that optimal blood pressure control with medical therapy after COA repair may result in improved clinical outcomes.

Original languageEnglish (US)
Pages (from-to)672-680
Number of pages9
JournalHypertension
DOIs
StateAccepted/In press - 2021

Keywords

  • aorta
  • blood pressure
  • heart disease
  • hypertrophy
  • tachycardia, ventricular

ASJC Scopus subject areas

  • Internal Medicine

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