Persistent effect of sustained hyperglucagonemia on glucose production in man

R. A. Rizza, J. E. Gerich

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

In man prolonged infusions of glucagon cause a transient increase in glucose production. To determine whether this represents complete loss of effect of hyperglucagonemia on the liver or merely decreased hepatic responsiveness, glucagon (3 ng/kg/min) was infused in six normal subjects to produce sustained hyperglucagonemia for 180 min; at this time glucagon infusions were stopped for 60 min, then restarted at the same rate for 60 min and finally increased to 7.5 ng/kg/min for 30 min. Glucose production (Ra) and utilization (Rd) were measured isotopically. Initially glucagon infusion increased Ra transiently from 1.8±0.1 mg/kg/min to a maximum at 15 min of 2.5±0.2 mg/kg/min (p<.01); Ra returned to basal values by 60 min and remained there until the glucagon infusion was stopped, whereupon it abruptly declined to a nadir of 1.4±0.1 mg/kg/min, a value significantly below baseline levels, p<.005. Upon restarting the glucagon infusion, Ra increased to a similar extent as observed with the initial infusion and then returned to basal levels; when the glucagon infusion rate was increased to 7.5 ng/kg/min, Ra again increased. These results indicate that sustained hyperglucagonemia, despite apparent waning of its effect, continues to modulate hapatic glucose production.

Original languageEnglish (US)
Pages (from-to)352-355
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume48
Issue number2
StatePublished - 1979

Fingerprint

Glucagon
Glucose
Liver

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Persistent effect of sustained hyperglucagonemia on glucose production in man. / Rizza, R. A.; Gerich, J. E.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 48, No. 2, 1979, p. 352-355.

Research output: Contribution to journalArticle

@article{a96e7a084db6450e9946cf650c5bfc8a,
title = "Persistent effect of sustained hyperglucagonemia on glucose production in man",
abstract = "In man prolonged infusions of glucagon cause a transient increase in glucose production. To determine whether this represents complete loss of effect of hyperglucagonemia on the liver or merely decreased hepatic responsiveness, glucagon (3 ng/kg/min) was infused in six normal subjects to produce sustained hyperglucagonemia for 180 min; at this time glucagon infusions were stopped for 60 min, then restarted at the same rate for 60 min and finally increased to 7.5 ng/kg/min for 30 min. Glucose production (Ra) and utilization (Rd) were measured isotopically. Initially glucagon infusion increased Ra transiently from 1.8±0.1 mg/kg/min to a maximum at 15 min of 2.5±0.2 mg/kg/min (p<.01); Ra returned to basal values by 60 min and remained there until the glucagon infusion was stopped, whereupon it abruptly declined to a nadir of 1.4±0.1 mg/kg/min, a value significantly below baseline levels, p<.005. Upon restarting the glucagon infusion, Ra increased to a similar extent as observed with the initial infusion and then returned to basal levels; when the glucagon infusion rate was increased to 7.5 ng/kg/min, Ra again increased. These results indicate that sustained hyperglucagonemia, despite apparent waning of its effect, continues to modulate hapatic glucose production.",
author = "Rizza, {R. A.} and Gerich, {J. E.}",
year = "1979",
language = "English (US)",
volume = "48",
pages = "352--355",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - Persistent effect of sustained hyperglucagonemia on glucose production in man

AU - Rizza, R. A.

AU - Gerich, J. E.

PY - 1979

Y1 - 1979

N2 - In man prolonged infusions of glucagon cause a transient increase in glucose production. To determine whether this represents complete loss of effect of hyperglucagonemia on the liver or merely decreased hepatic responsiveness, glucagon (3 ng/kg/min) was infused in six normal subjects to produce sustained hyperglucagonemia for 180 min; at this time glucagon infusions were stopped for 60 min, then restarted at the same rate for 60 min and finally increased to 7.5 ng/kg/min for 30 min. Glucose production (Ra) and utilization (Rd) were measured isotopically. Initially glucagon infusion increased Ra transiently from 1.8±0.1 mg/kg/min to a maximum at 15 min of 2.5±0.2 mg/kg/min (p<.01); Ra returned to basal values by 60 min and remained there until the glucagon infusion was stopped, whereupon it abruptly declined to a nadir of 1.4±0.1 mg/kg/min, a value significantly below baseline levels, p<.005. Upon restarting the glucagon infusion, Ra increased to a similar extent as observed with the initial infusion and then returned to basal levels; when the glucagon infusion rate was increased to 7.5 ng/kg/min, Ra again increased. These results indicate that sustained hyperglucagonemia, despite apparent waning of its effect, continues to modulate hapatic glucose production.

AB - In man prolonged infusions of glucagon cause a transient increase in glucose production. To determine whether this represents complete loss of effect of hyperglucagonemia on the liver or merely decreased hepatic responsiveness, glucagon (3 ng/kg/min) was infused in six normal subjects to produce sustained hyperglucagonemia for 180 min; at this time glucagon infusions were stopped for 60 min, then restarted at the same rate for 60 min and finally increased to 7.5 ng/kg/min for 30 min. Glucose production (Ra) and utilization (Rd) were measured isotopically. Initially glucagon infusion increased Ra transiently from 1.8±0.1 mg/kg/min to a maximum at 15 min of 2.5±0.2 mg/kg/min (p<.01); Ra returned to basal values by 60 min and remained there until the glucagon infusion was stopped, whereupon it abruptly declined to a nadir of 1.4±0.1 mg/kg/min, a value significantly below baseline levels, p<.005. Upon restarting the glucagon infusion, Ra increased to a similar extent as observed with the initial infusion and then returned to basal levels; when the glucagon infusion rate was increased to 7.5 ng/kg/min, Ra again increased. These results indicate that sustained hyperglucagonemia, despite apparent waning of its effect, continues to modulate hapatic glucose production.

UR - http://www.scopus.com/inward/record.url?scp=0018740985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018740985&partnerID=8YFLogxK

M3 - Article

C2 - 429489

AN - SCOPUS:0018740985

VL - 48

SP - 352

EP - 355

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 2

ER -