TY - JOUR
T1 - Persistent Disparities among Patients with T-Cell Non-Hodgkin Lymphomas and B-Cell Diffuse Large Cell Lymphomas over 40 Years
T2 - A SEER Database Review
AU - Crozier, Jennifer A.
AU - Sher, Taimur
AU - Yang, Dongyun
AU - Swaika, Abhisek
AU - Foran, James
AU - Ghosh, Radhika
AU - Tun, Han
AU - Colon-Otero, Gerardo
AU - Kelly, Kevin
AU - Chanan-Khan, Asher
AU - Ailawadhi, Sikander
N1 - Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Background As of 2013, more than 550,000 people are living with non-Hodgkin lymphoma (NHL). Patients and Methods We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to describe outcome disparities in different subgroups of aggressive T-cell and B-cell NHL patients, with a focus on various ethnicities. Results The final analysis included 7662 patients with T-cell and 84,910 with B-cell NHL. Survival analysis revealed that male sex and increasing age were independent predictors of worse overall survival (OS; P <.001). For aggressive T-cell NHL, there was no significant improvement in median OS between 1973 and 2011 (P =.081), and ethnic minorities (Asians, Hispanics, and African Americans) had significantly worse OS than whites (P <.001). There were similar trends for age, sex, and race for diffuse large B-cell NHL, but a significant improvement in median OS was seen over time (P <.001). Conclusion These results are the first to elicit outcomes in a broad classification of ethnic minorities and underscore the urgency for development of novel therapeutics, especially in T-cell NHL. In addition, in-depth studies of disease biology and health care utilization are required for better triage of health care resources, especially for ethnic minorities.
AB - Background As of 2013, more than 550,000 people are living with non-Hodgkin lymphoma (NHL). Patients and Methods We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to describe outcome disparities in different subgroups of aggressive T-cell and B-cell NHL patients, with a focus on various ethnicities. Results The final analysis included 7662 patients with T-cell and 84,910 with B-cell NHL. Survival analysis revealed that male sex and increasing age were independent predictors of worse overall survival (OS; P <.001). For aggressive T-cell NHL, there was no significant improvement in median OS between 1973 and 2011 (P =.081), and ethnic minorities (Asians, Hispanics, and African Americans) had significantly worse OS than whites (P <.001). There were similar trends for age, sex, and race for diffuse large B-cell NHL, but a significant improvement in median OS was seen over time (P <.001). Conclusion These results are the first to elicit outcomes in a broad classification of ethnic minorities and underscore the urgency for development of novel therapeutics, especially in T-cell NHL. In addition, in-depth studies of disease biology and health care utilization are required for better triage of health care resources, especially for ethnic minorities.
KW - Ethnic and racial minorities
KW - NHL
KW - Outcome
KW - Survival
KW - Treatment
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U2 - 10.1016/j.clml.2015.06.005
DO - 10.1016/j.clml.2015.06.005
M3 - Article
C2 - 26198444
AN - SCOPUS:84942830105
SN - 2152-2650
VL - 15
SP - 578
EP - 585
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 10
ER -