Persistent Disparities among Patients with T-Cell Non-Hodgkin Lymphomas and B-Cell Diffuse Large Cell Lymphomas over 40 Years: A SEER Database Review

Jennifer A. Crozier, Taimur Sher, Dongyun Yang, Abhisek Swaika, James Foran, Radhika Ghosh, Han Tun, Gerardo Colon-Otero, Kevin Kelly, Asher Chanan-Khan, Sikander Ailawadhi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background As of 2013, more than 550,000 people are living with non-Hodgkin lymphoma (NHL). Patients and Methods We undertook a large Surveillance Epidemiology and End Results (SEER) based analysis to describe outcome disparities in different subgroups of aggressive T-cell and B-cell NHL patients, with a focus on various ethnicities. Results The final analysis included 7662 patients with T-cell and 84,910 with B-cell NHL. Survival analysis revealed that male sex and increasing age were independent predictors of worse overall survival (OS; P <.001). For aggressive T-cell NHL, there was no significant improvement in median OS between 1973 and 2011 (P =.081), and ethnic minorities (Asians, Hispanics, and African Americans) had significantly worse OS than whites (P <.001). There were similar trends for age, sex, and race for diffuse large B-cell NHL, but a significant improvement in median OS was seen over time (P <.001). Conclusion These results are the first to elicit outcomes in a broad classification of ethnic minorities and underscore the urgency for development of novel therapeutics, especially in T-cell NHL. In addition, in-depth studies of disease biology and health care utilization are required for better triage of health care resources, especially for ethnic minorities.

Original languageEnglish (US)
Pages (from-to)578-585
Number of pages8
JournalClinical Lymphoma, Myeloma and Leukemia
Volume15
Issue number10
DOIs
StatePublished - Oct 1 2015

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Keywords

  • Ethnic and racial minorities
  • NHL
  • Outcome
  • Survival
  • Treatment

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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