Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Yasuo Inoshima, Yasuhiro H Ikeda, Mariko Kohmoto, Marcelo Ricardo Pecoraro, Masayuki Shimojima, Yukako Shimojima, Gouki Inada, Yasushi Kawaguchi, Keizo Tomonaga, Takayuki Miyazawa, Takeshi Mikami

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalJournal of Veterinary Medical Science
Volume58
Issue number9
StatePublished - Sep 1996
Externally publishedYes

Fingerprint

Feline Immunodeficiency Virus
Feline immunodeficiency virus
Neutralizing Antibodies
neutralizing antibodies
Cats
cats
Viruses
viruses
assays
RNA-Directed DNA Polymerase
Felidae
Virus Diseases
RNA-directed DNA polymerase
defense mechanisms
neutralization
Observation
Cell Line
T-lymphocytes
cell lines
Antibody

Keywords

  • Antibody
  • FIV
  • Neutralization test

ASJC Scopus subject areas

  • Marketing
  • veterinary(all)

Cite this

Inoshima, Y., Ikeda, Y. H., Kohmoto, M., Pecoraro, M. R., Shimojima, M., Shimojima, Y., ... Mikami, T. (1996). Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. Journal of Veterinary Medical Science, 58(9), 925-927.

Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. / Inoshima, Yasuo; Ikeda, Yasuhiro H; Kohmoto, Mariko; Pecoraro, Marcelo Ricardo; Shimojima, Masayuki; Shimojima, Yukako; Inada, Gouki; Kawaguchi, Yasushi; Tomonaga, Keizo; Miyazawa, Takayuki; Mikami, Takeshi.

In: Journal of Veterinary Medical Science, Vol. 58, No. 9, 09.1996, p. 925-927.

Research output: Contribution to journalArticle

Inoshima, Y, Ikeda, YH, Kohmoto, M, Pecoraro, MR, Shimojima, M, Shimojima, Y, Inada, G, Kawaguchi, Y, Tomonaga, K, Miyazawa, T & Mikami, T 1996, 'Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus', Journal of Veterinary Medical Science, vol. 58, no. 9, pp. 925-927.
Inoshima, Yasuo ; Ikeda, Yasuhiro H ; Kohmoto, Mariko ; Pecoraro, Marcelo Ricardo ; Shimojima, Masayuki ; Shimojima, Yukako ; Inada, Gouki ; Kawaguchi, Yasushi ; Tomonaga, Keizo ; Miyazawa, Takayuki ; Mikami, Takeshi. / Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. In: Journal of Veterinary Medical Science. 1996 ; Vol. 58, No. 9. pp. 925-927.
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