Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Yasuo Inoshima, Yasuhiro Ikeda, Mariko Kohmoto, Marcelo Ricardo Pecoraro, Masayuki Shimojima, Yukako Shimojima, Gouki Inada, Yasushi Kawaguchi, Keizo Tomonaga, Takayuki Miyazawa, Takeshi Mikami

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalJournal of Veterinary Medical Science
Volume58
Issue number9
DOIs
StatePublished - Sep 1996

Keywords

  • Antibody
  • FIV
  • Neutralization test

ASJC Scopus subject areas

  • veterinary(all)

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    Inoshima, Y., Ikeda, Y., Kohmoto, M., Pecoraro, M. R., Shimojima, M., Shimojima, Y., Inada, G., Kawaguchi, Y., Tomonaga, K., Miyazawa, T., & Mikami, T. (1996). Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. Journal of Veterinary Medical Science, 58(9), 925-927. https://doi.org/10.1292/jvms.58.925