Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Yasuo Inoshima; Yasuhiro Ikeda; Mariko Kohmoto; Marcelo Ricardo Pecoraro; Masayuki Shimojima; Yukako Shimojima; Gouki Inada; Yasushi Kawaguchi; Keizo Tomonaga; Takayuki Miyazawa; Takeshi Mikami

doi:10.1292/jvms.58.925

Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Yasuo Inoshima, Yasuhiro Ikeda, Mariko Kohmoto, Marcelo Ricardo Pecoraro, Masayuki Shimojima, Yukako Shimojima, Gouki Inada, Yasushi Kawaguchi, Keizo Tomonaga, Takayuki Miyazawa, Takeshi Mikami

Molecular Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

Original language	English (US)
Pages (from-to)	925-927
Number of pages	3
Journal	Journal of Veterinary Medical Science
Volume	58
Issue number	9
DOIs	https://doi.org/10.1292/jvms.58.925
State	Published - Sep 1996

Keywords

Antibody
FIV
Neutralization test

ASJC Scopus subject areas

General Veterinary

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10.1292/jvms.58.925

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Inoshima, Y., Ikeda, Y., Kohmoto, M., Pecoraro, M. R., Shimojima, M., Shimojima, Y., Inada, G., Kawaguchi, Y., Tomonaga, K., Miyazawa, T., & Mikami, T. (1996). Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. Journal of Veterinary Medical Science, 58(9), 925-927. https://doi.org/10.1292/jvms.58.925

Inoshima, Y, Ikeda, Y, Kohmoto, M, Pecoraro, MR, Shimojima, M, Shimojima, Y, Inada, G, Kawaguchi, Y, Tomonaga, K, Miyazawa, T & Mikami, T 1996, 'Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus', Journal of Veterinary Medical Science, vol. 58, no. 9, pp. 925-927. https://doi.org/10.1292/jvms.58.925

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abstract = "The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.",

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author = "Yasuo Inoshima and Yasuhiro Ikeda and Mariko Kohmoto and Pecoraro, {Marcelo Ricardo} and Masayuki Shimojima and Yukako Shimojima and Gouki Inada and Yasushi Kawaguchi and Keizo Tomonaga and Takayuki Miyazawa and Takeshi Mikami",

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AU - Inoshima, Yasuo

AU - Ikeda, Yasuhiro

AU - Kohmoto, Mariko

AU - Pecoraro, Marcelo Ricardo

AU - Shimojima, Masayuki

AU - Shimojima, Yukako

AU - Inada, Gouki

AU - Kawaguchi, Yasushi

AU - Tomonaga, Keizo

AU - Miyazawa, Takayuki

AU - Mikami, Takeshi

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AB - The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

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Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus

Abstract

Keywords

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