Persistence of hepatitis C virus in peripheral blood mononuclear cells of sustained viral responders to pegylated interferon and ribavirin therapy

Juan F. Gallegos-Orozco, Jorge Rakela, Marianne J. Rosati, Hugo E. Vargas, Vijayan Balan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The aim of this paper was to assess the persistence of hepatitis C virus (HCV) among patients successfully treated with peginterferon and ribavirin. The persistence of viral RNA was evaluated in the serum and peripheral blood mononuclear cells (PBMCs) of 25 chronic hepatitis C patients with sustained viral response to peginterferon and ribavirin treatment up to 56 months after the completion of therapy. Viral RNA was detected in the peripheral blood mononuclear cell cultures of five patients (20%), but none had detectable serum HCV RNA. At present, the clinical relevance of this finding is unclear. It is possible that viral persistence and, specifically, the presence of HCV RNA in PBMCs may lead to HCV reactivation under special circumstances, such as immunosuppression.

Original languageEnglish (US)
Pages (from-to)2564-2568
Number of pages5
JournalDigestive diseases and sciences
Volume53
Issue number9
DOIs
StatePublished - Sep 1 2008

Keywords

  • Hepatitis C virus
  • Peginterferon
  • Peripheral blood mononuclear cells
  • Viral hepatitis
  • Viral persistence

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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