Permeabilization and recovery of the stratum corneum in vivo

The synergy of photomechanical waves and sodium lauryl sulfate

Shun Lee, Daniel J. McAuliffe, Nikiforos Kollias, Thomas J Flotte, Apostolos G. Doukas

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background and Objective: Photomechanical waves render the stratum corneum permeable and allow macromolecules to diffuse into the epidermis and dermis. The aim of this study was to investigate the combined action of photomechanical waves and sodium lauryl sulfate, an anionic surfactant, for transdermal delivery. Study Design/Materials and Methods: A single photo-mechanical wave was applied to the skin of rats in the presence of sodium lauryl sulfate. The sodium lauryl sulfate solution was removed and aqueous solutions of rhodamine-B dextran (40 kDa molecular weight) were applied to the skin at time points 2, 30, and 60 minutes post-exposure. The presence of rhodamine-B dextran in the skin was measured by fluorescence emission spectroscopy in vivo and fluorescence microscopy of frozen biopsies. Results: The use of sodium lauryl sulfate delayed the recovery of the stratum corneum barrier and extended the time available for the diffusion of dextran through it. Conclusion: The combination of photomechanical waves and surfactants can enhance transdermal drug delivery.

Original languageEnglish (US)
Pages (from-to)145-150
Number of pages6
JournalLasers in Surgery and Medicine
Volume29
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

rhodamine B
Sodium Dodecyl Sulfate
Cornea
Dextrans
Surface-Active Agents
Skin
Fluorescence Spectrometry
Dermis
Fluorescence Microscopy
Epidermis
Molecular Weight
Biopsy
Pharmaceutical Preparations
rhodamine dextran

Keywords

  • Drug delivery
  • Shock waves
  • Sodium lauryl sulfate
  • Stratum corneum barrier
  • Transdermal delivery

ASJC Scopus subject areas

  • Surgery

Cite this

Permeabilization and recovery of the stratum corneum in vivo : The synergy of photomechanical waves and sodium lauryl sulfate. / Lee, Shun; McAuliffe, Daniel J.; Kollias, Nikiforos; Flotte, Thomas J; Doukas, Apostolos G.

In: Lasers in Surgery and Medicine, Vol. 29, No. 2, 2001, p. 145-150.

Research output: Contribution to journalArticle

Lee, Shun ; McAuliffe, Daniel J. ; Kollias, Nikiforos ; Flotte, Thomas J ; Doukas, Apostolos G. / Permeabilization and recovery of the stratum corneum in vivo : The synergy of photomechanical waves and sodium lauryl sulfate. In: Lasers in Surgery and Medicine. 2001 ; Vol. 29, No. 2. pp. 145-150.
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