Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Peter James Dyck, Alfred C. Lais, Jeannine L. Karnes, Margaret Sparks, Heidi Hunder, Phillip A. Low, Anthony J. Windebank

Research output: Contribution to journalArticle

118 Scopus citations

Abstract

Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.

Original languageEnglish (US)
Pages (from-to)575-583
Number of pages9
JournalAnnals of neurology
Volume9
Issue number6
DOIs
StatePublished - Jun 1981

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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