Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Peter James Dyck; Alfred C. Lais; Jeannine L. Karnes; Margaret Sparks; Heidi Hunder; Phillip A. Low; Anthony J. Windebank

doi:10.1002/ana.410090611

Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Peter James Dyck, Alfred C. Lais, Jeannine L. Karnes, Margaret Sparks, Heidi Hunder, Phillip A. Low, Anthony J. Windebank

Neurology

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.

Original language	English (US)
Pages (from-to)	575-583
Number of pages	9
Journal	Annals of neurology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1002/ana.410090611
State	Published - Jun 1981

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/ana.410090611

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title = "Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination",

abstract = "Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.",

author = "Dyck, {Peter James} and Lais, {Alfred C.} and Karnes, {Jeannine L.} and Margaret Sparks and Heidi Hunder and Low, {Phillip A.} and Windebank, {Anthony J.}",

year = "1981",

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doi = "10.1002/ana.410090611",

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AU - Dyck, Peter James

AU - Lais, Alfred C.

AU - Karnes, Jeannine L.

AU - Sparks, Margaret

AU - Hunder, Heidi

AU - Low, Phillip A.

AU - Windebank, Anthony J.

PY - 1981/6

Y1 - 1981/6

N2 - Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.

AB - Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.

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ER -

Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Abstract

ASJC Scopus subject areas

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