Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination

Peter J Dyck, Alfred C. Lais, Jeannine L. Karnes, Margaret Sparks, Heidi Hunder, Phillip Anson Low, Anthony John Windebank

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.

Original languageEnglish (US)
Pages (from-to)575-583
Number of pages9
JournalAnnals of Neurology
Volume9
Issue number6
DOIs
StatePublished - 1981

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Axotomy
Demyelinating Diseases
Atrophy
Friedreich Ataxia
Myelinated Nerve Fibers
Myelin Sheath
Cats
Extremities

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination. / Dyck, Peter J; Lais, Alfred C.; Karnes, Jeannine L.; Sparks, Margaret; Hunder, Heidi; Low, Phillip Anson; Windebank, Anthony John.

In: Annals of Neurology, Vol. 9, No. 6, 1981, p. 575-583.

Research output: Contribution to journalArticle

Dyck, Peter J ; Lais, Alfred C. ; Karnes, Jeannine L. ; Sparks, Margaret ; Hunder, Heidi ; Low, Phillip Anson ; Windebank, Anthony John. / Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination. In: Annals of Neurology. 1981 ; Vol. 9, No. 6. pp. 575-583.
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