Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis

Russell H. Wiesner, Nicholas F. LaRusso, Roger R. Dozois, Sandra J. Beaver

Research output: Contribution to journalArticle

99 Scopus citations

Abstract

Primary sclerosing cholangitis is a chronic cholestatic liver disease that is commonly associated with chronic ulcerative colitis. We observed the development of varices in the abdominal wall surrounding the ileostomy stoma of patients with primary sclerosing cholangitis who underwent proctocolectomy and ileostomy for chronic ulcerative colitis. In 10 of 19 patients, the development of peristomal varices was documented 12-133 mo after operation. Risk factors for the development of peristomal varices included splenomegaly, esophageal varices, advanced histologic stage at liver biopsy, low serum albumin, thrombocytopenia, and an increased prothrombin time. Recurrent bleeding from peristomal varices was a major problem; 7 of 10 patients required repeated blood transfusions. The only therapy of long-term benefit was surgical decompression of the portal venous system in 1 patient and liver transplantation in a second patient. In contrast, there was no perirectal bleeding in 4 patients with primary sclerosing cholangitis who underwent proctocolectomy with an ileoanal anastomosis.

Original languageEnglish (US)
Pages (from-to)316-322
Number of pages7
JournalGastroenterology
Volume90
Issue number2
DOIs
StatePublished - Feb 1986

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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